Quinolone-resistant Neisseria gonorrhoeae: Correlation of alterations in the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV with antimicrobial susceptibility profiles

被引：99
|
作者：
Deguchi, T
Yasuda, M
Nakano, M
Ozeki, S
Ezaki, T
Saito, I
Kawada, Y
机构：
[1] GIFU UNIV,SCH MED,DEPT MICROBIOL,GIFU 500,JAPAN
[2] TOKYO KYOSAI HOSP,DEPT UROL,TOKYO,JAPAN
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1996年 / 40卷 / 04期
关键词：
D O I：
10.1128/AAC.40.4.1020
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Fifty-five clinical strains of Neisseria gonorrhoeae were examined for mutations in the gyrA and parC genes and for antimicrobial susceptibility profiles. The MICs of quinolones for 31 strains with alterations in GyrA were significantly higher than the MICs for 24 strains without such alterations. Eleven strains with alterations in both GyrA and ParC were significantly more resistant to fluoroquinolones than those with alterations in GyrA alone. The MICs of cephalosporins for these strains were also significantly higher than those for other strains.
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页码：1020 / 1023
页数：4
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