The changing landscape of ischaemic brain injury mechanisms

被引：929
|
作者：
Lee, JM [1 ]
Zipfel, GJ
Choi, DW
机构：
[1] Washington Univ, Sch Med, Ctr Study Nervous Syst Injury, St Louis, MO 63110 USA
[2] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA
来源：
NATURE | 1999年 / 399卷 / 6738期
关键词：
D O I：
10.1038/399a007
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Thrombolysis has become established as an acute treatment for human stroke. But despite multiple clinical trials, neuroprotective strategies have yet to be proved effective in humans. Here we discuss intrinsic tissue mechanisms of ischaemic brain injury, and present a perspective that broadening of therapeutic targeting beyond excitotoxicity and neuronal calcium overload will be desirable for developing the most effective neuroprotective therapies.
引用
收藏
页码：A7 / A14
页数：8
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