Downregulation of Transcription Factor LRF/ZBTB7A Increases Fetal Hemoglobin Expression in β-Thalassemia/Hemoglobin E Erythroid Cells

被引：3
|
作者：
Chumchuen, Sukanya [1 ]
Pornsukjantra, Tanapat [2 ]
Khamphikham, Pinyaphat [3 ]
Anurathapan, Usanarat [4 ]
Sripichai, Orapan [5 ]
Songdej, Duantida [4 ]
Hongeng, Suradej [4 ]
机构：
[1] Mahidol Univ, Ramathibodi Hosp, Res Ctr, Fac Med, Bangkok, Thailand
[2] Mahidol Univ, Ramathibodi Hosp, Program Translat Med, Fac Med, Bangkok, Thailand
[3] Thammasat Univ, Fac Allied Hlth Sci, Dept Forens Sci, Pathum Thani, Thailand
[4] Mahidol Univ, Fac Med, Dept Pediat, Ramathibodi Hosp, Bangkok, Thailand
[5] Minist Publ Hlth, Natl Inst Hlth, Dept Med Sci, Nonthaburi, Thailand
来源：
BLOOD | 2019年 / 134卷
关键词：
D O I：
10.1182/blood-2019-126664
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
3549
引用
收藏
页数：3
相关论文
共 50 条
  • [1] The LRF/ZBTB7A Transcription Factor Is a BCL11A-Independent Repressor of Fetal Hemoglobin
    Masuda, Takeshi
    Wang, Xin
    Maeda, Manami
    Canver, Matthew C.
    Sher, Falak
    Funnell, Alister P. W.
    Fisher, Chris
    Suciu, Maria
    Martyn, Gabriella E.
    Norton, Laura J.
    Zhu, Ruijia
    Kurita, Ryo
    Nakamura, Yukio
    Xu, Jian
    Higgs, Douglas R.
    Crossley, Merlin
    Bauer, Daniel E.
    Orkin, Stuart H.
    Kharchenko, Peter V.
    Maeda, Takahiro
    BLOOD, 2015, 126 (23)
  • [2] KLF1 directly activates expression of the novel fetal globin repressor ZBTB7A/LRF in erythroid cells
    Norton, Laura J.
    Funnell, Alister P. W.
    Burdach, Jon
    Wienert, Beeke
    Kurita, Ryo
    Nakamura, Yukio
    Philipsen, Sjaak
    Pearson, Richard C. M.
    Quinlan, Kate G. R.
    Crossley, Merlin
    BLOOD ADVANCES, 2017, 1 (11) : 685 - 692
  • [3] Nine known and five novel mutations in the erythroid transcription factor KLF1 gene and phenotypic expression of fetal hemoglobin in hemoglobin E disorder
    Tepakhan, Wanicha
    Yamsri, Supawadee
    Sanchaisuriya, Kanokwan
    Fucharoen, Goonnapa
    Xu, Xiangmin
    Fucharoen, Supan
    BLOOD CELLS MOLECULES AND DISEASES, 2016, 59 : 85 - 91
  • [4] Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin
    Masuda, Takeshi
    Wang, Xin
    Maeda, Manami
    Canver, Matthew C.
    Sher, Falak
    Funnell, Alister P. W.
    Fisher, Chris
    Suciu, Maria
    Martyn, Gabriella E.
    Norton, Laura J.
    Zhu, Catherine
    Kurita, Ryo
    Nakamura, Yukio
    Xu, Jian
    Higgs, Douglas R.
    Crossley, Merlin
    Bauer, Daniel E.
    Orkin, Stuart H.
    Kharchenko, Peter V.
    Maeda, Takahiro
    SCIENCE, 2016, 351 (6270) : 285 - 289
  • [5] STOCHASTIC EXPRESSION OF FETAL HEMOGLOBIN IN ADULT ERYTHROID-CELLS
    STAMATOYANNOPOULOS, G
    KURNIT, DM
    PAPAYANNOPOULOU, T
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (11): : 7005 - 7009
  • [6] UNC0638 induces high levels of fetal hemoglobin expression in β-thalassemia/HbE erythroid progenitor cells
    Tiwaporn Nualkaew
    Pinyaphat Khamphikham
    Phitchapa Pongpaksupasin
    Woratree Kaewsakulthong
    Duantida Songdej
    Kittiphong Paiboonsukwong
    Orapan Sripichai
    James Douglas Engel
    Suradej Hongeng
    Suthat Fucharoen
    Natee Jearawiriyapaisarn
    Annals of Hematology, 2020, 99 : 2027 - 2036
  • [7] UNC0638 induces high levels of fetal hemoglobin expression in β-thalassemia/HbE erythroid progenitor cells
    Nualkaew, Tiwaporn
    Khamphikham, Pinyaphat
    Pongpaksupasin, Phitchapa
    Kaewsakulthong, Woratree
    Songdej, Duantida
    Paiboonsukwong, Kittiphong
    Sripichai, Orapan
    Engel, James Douglas
    Hongeng, Suradej
    Fucharoen, Suthat
    Jearawiriyapaisarn, Natee
    ANNALS OF HEMATOLOGY, 2020, 99 (09) : 2027 - 2036
  • [8] Global mapping of ZBTB7A transcription factor binding sites in HepG2 cells
    Zu, Xuyu
    Yu, Lingling
    Sun, Yiming
    Tian, Jing
    Liu, Feng
    Sun, Qinsheng
    He, Shengnan
    Sun, Guang
    Luo, Weishi
    Jiang, Yuyang
    CELLULAR & MOLECULAR BIOLOGY LETTERS, 2010, 15 (02) : 260 - 271
  • [9] Disruption of the BCL11A Erythroid Enhancer Reactivates Fetal Hemoglobin in Erythroid Cells of Patients with β-Thalassemia Major
    Psatha, Nikoletta
    Reik, Andreas
    Phelps, Susan
    Zhou, Yuanyue
    Dalas, Demetri
    Yannaki, Evangelia
    Levasseur, Dana N.
    Urnov, Fyodor D.
    Holmes, Michael C.
    Papayannopoulou, Thalia
    MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT, 2018, 10 : 313 - 326
  • [10] Global mapping of ZBTB7A transcription factor binding sites in HepG2 cells
    Xuyu Zu
    Lingling Yu
    Yiming Sun
    Jing Tian
    Feng Liu
    Qinsheng Sun
    Shengnan He
    Guang Sun
    Weishi Luo
    Yuyang Jiang
    Cellular & Molecular Biology Letters, 2010, 15 : 260 - 271
12345