The Future of Asthma Care Personalized Asthma Treatment

被引：9

作者：

Holgate, Stephen T. ^{[1
]}

Walker, Samantha ^{[2
]}

West, Brigitte ^{[2
]}

Boycott, Kay ^{[2
]}

机构：

[1] Univ Southampton, Southampton Gen Hosp, Sir Henry Wellcome Res Labs, Clin & Expt Sci,Fac Med, Mail Point 810, Southampton SO16 6YD, Hants, England

[2] Asthma UK, 18 Mansell St, London E1 8AA, England

来源：

CLINICS IN CHEST MEDICINE | 2019年 / 40卷 / 01期

基金：

英国医学研究理事会;

关键词：

Asthma; Personalized health care; Biologics; Companion diagnostics; mHealth; Digital self-management; INNATE LYMPHOID-CELLS; SELF-MANAGEMENT; EOSINOPHIL COUNTS; CLUSTER-ANALYSIS; MOBILE HEALTH; PHENOTYPES; EXACERBATIONS; LEBRIKIZUMAB; EXPRESSION; BIOMARKERS;

D O I：

10.1016/j.ccm.2018.10.013

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Although once considered a single disease entity, asthma is now known to be a complex inflammatory disease engaging a range of causal pathways. The most frequent forms of asthma are identified by sputum/blood eosinophilia and activation of type 2 inflammatory pathways involving interleukins-3, -4, -5, and granulocyte-macrophage colony-stimulating factor. The use of diagnostics that identify T2 engagement linked to the selective use of highly targeted biologics has opened up a new way of managing severe disease. Novel technologies, such as wearables and intelligent inhalers, enable real-time remote monitoring of asthma, creating a unique opportunity for personalized health care.

引用

页码：227 / +

页数：16

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