Breast cancer incidence after hormonal infertility treatment in Sweden: a cohort study

被引：45

作者：

Orgeas, Chantal C. ^{[1
,9
]}

Sanner, Karin ^{[1
,3
]}

Hall, Per ^{[1
]}

Conner, Peter ^{[2
]}

Holte, Jan ^{[4
]}

Nilsson, Staffan J. ^{[6
,7
]}

Sundfeldt, Karin ^{[8
]}

Persson, Ingemar ^{[1
,5
]}

Chia, Kee Seng ^{[9
,10
]}

Wedren, Sara ^{[1
]}

Dickman, Paul W. ^{[1
]}

Czene, Kamila ^{[1
]}

机构：

[1] Karolinska Inst, Dept Med Epidemiol & Biostat, SE-17177 Stockholm, Sweden

[2] Karolinska Univ Hosp, Dept Obstet & Gynecol, Stockholm, Sweden

[3] Univ Uppsala Hosp, Dept Womens & Childrens Hlth, Womens Clin Obstet & Gynecol, Uppsala, Sweden

[4] Carl von Linne Kliniken, Uppsala, Sweden

[5] Med Prod Agcy, Uppsala, Sweden

[6] Dalarna, Clin Res Ctr, Falun, Sweden

[7] Womens Clin Obstet & Gynecol, Dept Womens & Childrens Hlth, Falun, Sweden

[8] Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Dept Obstet & Gynecol, Gothenburg, Sweden

[9] Natl Univ Singapore, Yong Loo Lin Sch Med, Ctr Mol Epidemiol, Singapore, Singapore

[10] Genome Inst Singapore, Singapore, Singapore

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 2009年 / 200卷 / 01期

关键词：

breast cancer; cohort; hormone infertility treatment; incidence; Sweden; OVULATION INDUCTION; POSTMENOPAUSAL WOMEN; FERTILITY DRUGS; RISK; THERAPY; HEALTH; CARCINOGENESIS; PREVENTION; PREGNANCY; ESTROGENS;

D O I：

10.1016/j.ajog.2008.08.066

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

OBJECTIVE: To assess the impact of infertility treatment with causes of infertility on incidence of breast cancer. STUDY DESIGN: Historical prospective cohort study of 1135 women attending major university clinics for treatment of infertility in Sweden, 1961-1976. Women were classified as users of clomiphene citrate or gonadotropins, or a combination of both therapies. Standardized incidence ratios were calculated to estimate relative risk of breast cancer. RESULTS: We observed 54 cases of breast cancer during 1961-2004, which did not significantly exceed those expected. Users of high-dose clomiphene citrate had an almost 2-fold increased risk (standardized incidence ratio, 1.90; 95% confidence interval, 1.08-3.35). This association was more pronounced among women referred for nonovulatory factors, with 3-fold increased risk (standardized incidence ratio, 3.00; 95% confidence interval, 1.35-6.67). CONCLUSION: No overall increased risk for breast cancer was shown with infertility treatment. Women with nonovulatory causes treated with high-dose clomiphene citrate therapy may have an elevated risk for breast cancer.

引用

页码：72.e1 / 72.e7

页数：7

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