Dendritic amphiphiles of carbosilane dendrimers with peripheral PEG for drug encapsulation

被引：2
|
作者：
Li, Chunfang [1 ]
Li, Dongxiang [1 ]
Qiu, Chuanlong [1 ]
Hou, Wanguo [2 ]
机构：
[1] Qingdao Univ Sci & Technol, Coll Chem & Mol Engn, Lab Colloid & Funct Nanostruct, Qingdao 266042, Peoples R China
[2] Shandong Univ, Minist Educ, Key Lab Colloid & Interface Chem, Jinan 250100, Peoples R China
来源：
JOURNAL OF POLYMER RESEARCH | 2013年 / 20卷 / 08期
关键词：
Carbosilane dendrimer; Fluorescence; Encapsulation; Probe molecule; CORE-SHELL NANOCARRIERS; POLAR DYES; ARCHITECTURES;
D O I：
10.1007/s10965-013-0204-7
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Amphiphilic dendritic macromolecules are suitable for the noncovalent encapsulation of guest molecules and could potentially be applied in drug-delivery systems. In this work, amphiphilic carbosilane dendrimers with peripheral poly(ethylene glycol) (PEG) units were synthesized using a hydrosilylation reaction, and their encapsulation properties were studied by fluorescence spectroscopy, using pyrene as the probe molecule. The results showed that the encapsulating capacity of the dendrimers increased as the number of PEG units increased, and that it also depended to some degree on the dendrimer generation.
引用
收藏
页数：6
相关论文
共 50 条
  • [1] Dendritic amphiphiles of carbosilane dendrimers with peripheral PEG for drug encapsulation
    Chunfang Li
    Dongxiang Li
    Chuanlong Qiu
    Wanguo Hou
    [J]. Journal of Polymer Research, 2013, 20
  • [2] Carbosilane dendrimers as drug carriers
    Pedziwiatr, E.
    Chonco, L.
    Shcharbin, D.
    de Jesus, E.
    Bermejo, J. F.
    Ortega, P.
    de la Mata, F. J.
    Flores, J. C.
    Gomez, R.
    Klajnert, B.
    Munoz-Fernandez, M. A.
    Bryszewska, M.
    [J]. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2007, 37 : 79 - 79
  • [3] Carbosilane dendrimers: Drug and gene delivery applications
    Rabiee, Navid
    Ahmadvand, Shokooh
    Ahmadi, Sepideh
    Fatahi, Yousef
    Dinarvand, Rassoul
    Bagherzadeh, Mojtaba
    Rabiee, Mohammad
    Tahriri, Mohammadreza
    Tayebi, Lobat
    Hamblin, Michael R.
    [J]. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2020, 59
  • [4] PREPARATION OF CARBOSILANE DENDRIMERS WITH PERIPHERAL ACETYLENEDICOBALT HEXACARBONYL SUBSTITUENTS
    SEYFERTH, D
    KUGITA, T
    RHEINGOLD, AL
    YAP, GPA
    [J]. ORGANOMETALLICS, 1995, 14 (11) : 5362 - 5366
  • [5] Synthesis of carbosilane dendrimers having peripheral mannose and mannobiose
    Mori, T
    Hatano, K
    Matsuoka, K
    Esumi, Y
    Toone, EJ
    Terunuma, D
    [J]. TETRAHEDRON, 2005, 61 (11) : 2751 - 2760
  • [6] Carbosilane Dendritic Amphiphiles from Cholesterol or Vitamin E for Micelle Formation
    Mencia, Gabriel
    Algar, Sergio
    Lozano-Cruz, Tania
    Munoz-Fernandez, M. angeles
    Gillies, Elizabeth R.
    Cano, Jesus
    Valiente, Mercedes
    Gomez, Rafael
    [J]. PHARMACEUTICS, 2024, 16 (04)
  • [7] Synthesis and property of carbosilane dendrimers functionalizing peripheral mannose moieties
    Mori, T
    Hatano, K
    Matsuoka, K
    Esumi, Y
    Toone, EJ
    Terunuma, D
    [J]. GLYCOBIOLOGY, 2004, 14 (11) : 1093 - 1093
  • [8] Mesogen-functionalized carbosilane dendrimers - Dendritic liquid crystalline polymers
    Frey, H
    Lorenz, K
    Holter, D
    Mulhaupt, R
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1996, 211 : 280 - POLY
  • [9] Amphiphilic Cationic Carbosilane-PEG Dendrimers: Synthesis and Applications in Gene Therapy
    Sanchez-Nieves, Javier
    Fransen, Peter
    Pulido, Daniel
    Lorente, Raquel
    Angeles Munoz-Fernandez, M.
    Albericio, Fernando
    Royo, Miriam
    Gomez, Rafael
    Javier de la Mata, E.
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 76 : 43 - 52
  • [10] Dendritic amphiphiles: Dendrimers having an amphiphile structure in each unit
    Ariga, K
    Urakawa, T
    Michiue, A
    Sasaki, Y
    Kikuchi, J
    [J]. LANGMUIR, 2000, 16 (24) : 9147 - 9150
12345