Phase I trial of neoadjuvant concurrent chemoradiotherapy with S-1 and weekly irinotecan in locally advanced rectal cancer

被引：10
|
作者：
Choi, Hye Jin [1 ]
Kim, Nam-Kyu [2 ]
Keum, Ki Chang [3 ]
Cheon, Seong Ha [1 ]
Shin, Sang Jun [1 ]
Baik, Seung Hyuk [2 ]
Choen, Jae Hee [1 ]
Rha, Sun Young [1 ,4 ]
Roh, Jae Kyung [1 ,4 ]
Jeung, Hei-Cheul [1 ,4 ]
Chung, Hyun Cheol [1 ,4 ]
Ahn, Joong Bae [1 ]
机构：
[1] Yonsei Univ, Coll Med, Dept Internal Med, Seoul 120752, South Korea
[2] Yonsei Univ, Coll Med, Dept Surg, Seoul 120752, South Korea
[3] Yonsei Univ, Coll Med, Dept Radiat Oncol, Seoul 120752, South Korea
[4] Yonsei Univ, Coll Med, Canc Metastasis Res Ctr, Seoul 120752, South Korea
来源：
RADIOTHERAPY AND ONCOLOGY | 2008年 / 87卷 / 03期
关键词：
S-1; irinotecan; neoadjuvant; rectal cancer;
D O I：
10.1016/j.radonc.2008.04.001
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
S-1 is a novel, oral fluoropyrimidine and a known radiosensitizer. We conducted a phase I trial to establish a schedule of S-1/irinotecan with standard pelvic radiotherapy as a preoperative treatment of locally advanced rectal cancer. Our findings suggest that this new combination is feasible and well tolerable. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：361 / 366
页数：6
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