HmGlu(1d), a novel splice variant of the human type I metabotropic glutamate receptor

A novel splice variant, hmGlu(1d), of the human mGlu(1) metabotropic glutamate receptor has been isolated from a human brain library. This clone is identical to human mGlu(1a) except that it lacks 35 nucleotides in the 3' coding sequence, which predicts a truncated protein and a novel carboxy terminus. After injection of the encoding sequence into mouse A9 fibroblasts, quisqualate and (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid ((1S,3R)-ACPD) elicited concentration-dependent increases in intracellular Ca2+ (pEC50 values of 6.09 and 4.33, respectively).