[Cp*RhCl2]2-catalyzed ortho-C-H bond amination of acetophenone o-methyloximes with primary N-chloroalkylamines: convenient synthesis of N-alkyl-2-acylanilines

被引：74

作者：

Ng, Ka-Ho

Zhou, Zhongyuan

Yu, Wing-Yiu ^{[1
]}

机构：

[1] Hong Kong Polytech Univ, State Key Lab Chirosci, Kowloon, Hong Kong, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 63期

关键词：

CATALYZED DIRECT AMINATION; TERT-BUTYL HYDROPEROXIDE; CARBENOID FUNCTIONALIZATION; ALDEHYDES; AMIDATION; ACTIVATION; CHLOROAMINES; ACETANILIDES; BENZOXAZOLES; CYCLIZATION;

D O I：

10.1039/c3cc42937g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Rh(III)-catalyzed aromatic C-H amination of acetophenone o-methyloximes with primary N-chloroalkylamines was developed, and the arylamine products were obtained in up to 92% yield. The reaction probably involves rate-limiting electrophilic C-H bond cleavage (k(H)/k(D) = 2).

引用

页码：7031 / 7033

页数：3

共 9 条

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