Pharmacophore-based identification of novel hERG channel blockers of natural origin - Development of a virtual screening workflow and experimental validation

被引：0
|
作者：
Kratz, J. M. [1 ,2 ]
Edtbauer, M. [3 ,4 ]
Mair, C. E. [1 ]
Hering, S. [5 ]
Schuster, D. [3 ,4 ]
Rollinger, J. M. [1 ]
机构：
[1] Univ Innsbruck, Ctr Mol Biosci Innsbruck, Inst Pharm Pharmacognosy, A-6020 Innsbruck, Austria
[2] Univ Fed Santa Catarina, Dept Ciencias Farmaceut, Florianopolis, SC, Brazil
[3] Univ Innsbruck, Comp Aided Mol Design Grp, Inst Pharm Pharmaceut Chem, A-6020 Innsbruck, Austria
[4] Univ Innsbruck, Ctr Mol Biosci Innsbruck, A-6020 Innsbruck, Austria
[5] Univ Vienna, Dept Pharmacol & Toxicol, A-1010 Vienna, Austria
来源：
PLANTA MEDICA | 2013年 / 79卷 / 13期
关键词：
D O I：
暂无
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
SL25
引用
收藏
页码：1113 / 1113
页数：1
相关论文
共 50 条
  • [1] Identification of Novel Rab27a/Melanophilin Blockers by Pharmacophore-Based Virtual Screening
    Joung, Jong Young
    Lee, Ha Yeon
    Park, Jongil
    Lee, Jee-Young
    Chang, Byung Ha
    No, Kyoung Tai
    Nam, Ky-Youb
    Hwang, Jae Sung
    APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 2014, 172 (04) : 1882 - 1897
  • [2] Identification of Novel Rab27a/Melanophilin Blockers by Pharmacophore-Based Virtual Screening
    Jong Young Joung
    Ha Yeon Lee
    Jongil Park
    Jee-Young Lee
    Byung Ha Chang
    Kyoung Tai No
    Ky-Youb Nam
    Jae Sung Hwang
    Applied Biochemistry and Biotechnology, 2014, 172 : 1882 - 1897
  • [3] Discovery of Novel TASK-3 Channel Blockers Using a Pharmacophore-Based Virtual Screening
    Ramirez, David
    Concha, Guierdy
    Arevalo, Barbara
    Prent-Penaloza, Luis
    Zuniga, Leandro
    Kiper, Aytug K.
    Rinne, Susanne
    Reyes-Parada, Miguel
    Decher, Niels
    Gonzalez, Wendy
    Caballero, Julio
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (16)
  • [4] Identification of Bioactive Natural Products by Pharmacophore-Based Virtual Screening
    Schuster, Daniela
    Wolber, Gerhard
    CURRENT PHARMACEUTICAL DESIGN, 2010, 16 (15) : 1666 - 1681
  • [5] Pharmacophore-based virtual screening - A valuable tool for the identification of bioactive natural products
    Stuppner, H.
    PLANTA MEDICA, 2012, 78 (11) : 1039 - 1039
  • [6] Discovery of Novel CB2 Receptor Ligands by a Pharmacophore-Based Virtual Screening Workflow
    Markt, Patrick
    Feldmann, Clemens
    Rollinger, Judith Maria
    Raduner, Stefan
    Schuster, Daniela
    Kirchmair, Johannes
    Distinto, Simona
    Spitzer, Gudrun Maria
    Wolber, Gerhard
    Laggner, Christian
    Altmann, Karl-Heinz
    Langer, Thierry
    Gertsch, Juerg
    JOURNAL OF MEDICINAL CHEMISTRY, 2009, 52 (02) : 369 - 378
  • [7] A novel structure-based virtual screening model for the hERG channel blockers
    Du, Lupei
    Li, Minyong
    You, Qidong
    Xia, Lin
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2007, 355 (04) : 889 - 894
  • [8] Identification of Natural Products as Novel PI3Kβ Inhibitors Through Pharmacophore-based Virtual Screening
    Jin, Xuemei
    Kwon, Woosun
    Kim, Tae Soo
    Heo, Jung-Nyoung
    Chung, Hyun Cheol
    Choi, Jiwon
    No, Kyoung Tai
    BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2018, 39 (03): : 294 - 299
  • [9] Identification of highly active natural thyroid hormone receptor agonists by pharmacophore-based virtual screening
    Tang, Shenjiao
    Sun, Lin
    Wang, Fangfang
    JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2021, 39 (03): : 901 - 910
  • [10] Pharmacophore-based Virtual Screening: Identification of Selective Sirtuin 2 Inhibitors
    Karaman Mayack, Berin
    Alayoubi, Muhammed Moyasar
    JOURNAL OF RESEARCH IN PHARMACY, 2023, 27 (04): : 1366 - 1379
12345