Ovarian cancer: involvement of the matrix metalloproteinases

被引:79
|
作者
Al-Alem, Linah [1 ]
Curry, Thomas E., Jr. [1 ]
机构
[1] Univ Kentucky, Med Ctr, Dept Obstet & Gynecol, Lexington, KY 40536 USA
基金
美国国家卫生研究院;
关键词
PROGNOSTIC-SIGNIFICANCE; INCESSANT OVULATION; CLINICAL-RELEVANCE; PROMOTES INVASION; TISSUE INHIBITORS; SIGNALING SYSTEM; CARCINOMA CELLS; MESSENGER-RNA; EXPRESSION; ACTIVATION;
D O I
10.1530/REP-14-0546
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Ovarian cancer is the leading cause of death from gynecologic malignancies. One of the reasons for the high mortality rate associated with ovarian cancer is its late diagnosis, which often occurs after the cancer has metastasized throughout the peritoneal cavity. Cancer metastasis is facilitated by the remodeling of the extracellular tumor matrix by a family of proteolytic enzymes known as the matrix metalloproteinases (MMPs). There are 23 members of the MMP family, many of which have been reported to be associated with ovarian cancer. In the current paradigm, ovarian tumor cells and the surrounding stromal cells stimulate the synthesis and/or activation of various MMPs to aid in tumor growth, invasion, and eventual metastasis. The present review sheds light on the different MMPs in the various types of ovarian cancer and on their impact on the progression of this gynecologic malignancy.
引用
收藏
页码:R55 / R64
页数:10
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