Allylic oxidation of steroidal olefins by vanadyl acetylacetonate and tert-butyl hydroperoxide

被引：6
|
作者：
Grainger, Wendell S. [1 ]
Parish, Edward J. [1 ]
机构：
[1] Auburn Univ, Coll Sci & Math, Dept Chem & Biochem, Auburn, AL 36849 USA
来源：
STEROIDS | 2015年 / 101卷
关键词：
Oxidation; 7-Ketocholesterol; Vanadyl acetylacetonate; tert-Butyl hydroperoxide; ASYMMETRIC EPOXIDATION; SPECTRAL PROPERTIES; MOLYBDENUM; 7-DEHYDROCHOLESTEROL; OXYSTEROLS; CATALYST; ALCOHOLS; ACETATE; STEROLS;
D O I：
10.1016/j.steroids.2015.06.005
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Readily available vanadyl acetylacetonate was found to oxidize the allylic sites of Delta(5) steroidal alcohols without protection of hydroxyl groups. Cholesterol, dehydroepiandrosterone, cholesterol benzoate, cholesterol acetate, pregnenolone, and 5-pregnen-3,20-diene were oxidized to 7-keto products using vanadyl acetylacetonate in one pot reactions at room temperature in the presence of oxygen and water. (C) 2015 Elsevier Inc. All rights reserved.
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页码：103 / 109
页数：7
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