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Synthesis and cytotoxicity evaluation of highly functionalized pyranochromenes and pyranopyrans
被引:47
|作者:
Emmadi, Narender Reddy
[1
]
Atmakur, Krishnaiah
[1
]
Chityal, Ganesh Kumar
[2
]
Pombala, Sujitha
[2
]
Nanubolu, Jagadeesh Babu
[3
]
机构:
[1] Indian Inst Chem Technol, Crop Protect Chem Div, Hyderabad 500607, Andhra Pradesh, India
[2] Indian Inst Chem Technol, Biol Chem Lab, Hyderabad 500607, Andhra Pradesh, India
[3] Indian Inst Chem Technol, Lab Xray Crystallog, Hyderabad 500607, Andhra Pradesh, India
关键词:
4-Hydroxy chromenes;
Ethyltrifluoro acetoacetate;
Aromatic aldehydes;
Tetrahydropyrano[3,2-c]chromenes;
Dihydropyrano[3,2-b]pyrans;
DERIVATIVES;
2-AMINO-2-CHROMENES;
CHEMISTRY;
CATALYST;
D O I:
10.1016/j.bmcl.2012.09.018
中图分类号:
R914 [药物化学];
学科分类号:
100701 ;
摘要:
A series of fluorinated tetrahydropyrano[3,2-c]chromenes and dihydropyrano[3,2-b]pyran derivatives have been synthesized and their in vitro cytotoxic activities have been determined in cervical cancer cell line (HeLa), human breast adenocarcinoma cell line (MDA-MB-231 and MCF-7) and human alveolar adenocarcinoma cell line (A549). Compounds 4g, 4k, 4p showed a very potent activity against MDA-MB-231, and 4c, 4p showed promising activity against MCF-7, while compounds 4c, 4g, 4p showed moderate activity against HeLa. (C) 2012 Elsevier Ltd. All rights reserved.
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页码:7261 / 7264
页数:4
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