Ficin-catalyzed asymmetric aldol reactions of heterocyclic ketones with aldehydes

被引：13
|
作者：
Fu, Jian-Ping [1 ]
Gao, Na [1 ]
Yang, Yang [1 ]
Guan, Zhi [1 ]
He, Yan-Hong [1 ]
机构：
[1] Southwest Univ, Sch Chem & Chem Engn, Chongqing 400715, Peoples R China
来源：
JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC | 2013年 / 97卷
基金：
中国国家自然科学基金;
关键词：
Enzymatic promiscuity; Ficin; Asymmetric aldol reaction; Heterocyclic ketones; BIOCATALYTIC PROMISCUITY; BONDS; MEDIA;
D O I：
10.1016/j.molcatb.2013.06.016
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Ficin from fig tree latex displayed a promiscuous activity to catalyze the direct asymmetric aldol reactions of heterocyclic ketones with aromatic aldehydes. Ficin showed good substrate adaptability to different heterocyclic ketones containing nitrogen, oxygen or sulfur. The enantioselectivities up to 81% ee and diastereoselectivities up to 86:14 (anti/syn) were achieved under the optimized reaction conditions. (C) 2013 Elsevier B.V. All rights reserved.
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页码：1 / 4
页数：4
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