How flexible is tipranavir in complex with the HIV-1 protease active site?

被引:6
|
作者
不详
机构
关键词
D O I
10.1097/01.aids.0000111429.91384.be
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
引用
下载
收藏
页码:579 / 580
页数:2
相关论文
共 50 条
  • [1] The active site of HIV-1 protease
    Mager, PP
    MEDICINAL RESEARCH REVIEWS, 2001, 21 (04) : 348 - 353
  • [2] The higher barrier of darunavir and tipranavir resistance for HIV-1 protease
    Wang, Yong
    Liu, Zhigang
    Brunzelle, Joseph S.
    Kovari, Iulia A.
    Dewdney, Tamaria G.
    Reiter, Samuel J.
    Kovari, Ladislau C.
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2011, 412 (04) : 737 - 742
  • [3] Investigation of the protonated state of HIV-1 protease active site
    Nam, KY
    Chang, BH
    Han, CK
    Ahn, SG
    No, KT
    BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2003, 24 (06) : 817 - 823
  • [4] Evaluation of triazolamers as active site inhibitors of HIV-1 protease
    Jochim, Andrea L.
    Miller, Stephen E.
    Angelo, Nicholas G.
    Arora, Paramjit S.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (21) : 6023 - 6026
  • [5] Tipranavir: a protease inhibitor for multi-drug resistant HIV-1
    Best, B
    Haubrich, R
    EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2006, 15 (01) : 59 - 70
  • [6] Active site binding modes of curcumin in HIV-1 protease and integrase
    Vajragupta, O
    Boonchoong, P
    Morris, GM
    Olson, AJ
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (14) : 3364 - 3368
  • [7] Atypical protonation states in the active site of HIV-1 protease: A computational study
    Czodrowski, Paul
    Sotriffer, Christoph A.
    Klebe, Gerhard
    JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2007, 47 (04) : 1590 - 1598
  • [8] In vitro susceptibility of HIV-1 to tipranavir
    Doyon, L
    Tremblay, S
    Cartier, M
    Cordingley, MG
    ANTIVIRAL THERAPY, 2002, 7 : S12 - S12
  • [9] Structure-function studies of HIV-1 protease drug resistance to tipranavir and darunavir
    Kovari, L. C.
    Wang, Y.
    Brunzelle, J.
    ANTIVIRAL THERAPY, 2011, 16 : A61 - A61
  • [10] Flexible catalytic site conformations implicated in modulation of HIV-1 protease autoprocessing reactions
    Huang, Liangqun
    Li, Yanfei
    Chen, Chaoping
    RETROVIROLOGY, 2011, 8 : 79