Development of a Discriminating In Vitro Dissolution Method for the Poorly Soluble Drug Rimonabant: Effect of Formulation Variables on Dosage Form Release Profiles

被引：0
|
作者：
Hurtado, Felipe K. [1 ]
Ravanello, Aline [1 ]
Torres, Bruna G. S. [1 ]
Souto, Gabriele D. [1 ]
Beck, Ruy Carlos R. [1 ]
Rolim, Clarice M. B. [1 ]
机构：
[1] Univ Fed Santa Maria, Dept Farm Ind, Programa Posgrad Ciencias Farmaceut, BR-97105900 Santa Maria, RS, Brazil
来源：
DISSOLUTION TECHNOLOGIES | 2012年 / 19卷 / 03期
关键词：
PARTICLE-SIZE REDUCTION; BEAGLE DOGS; IMPROVEMENT; STABILITY; TABLETS; SODIUM;
D O I：
10.14227/DT190312P30
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The effect of formulation parameters on the in vitro release profile of a poorly soluble drug was investigated using rimonabant as model drug. A dissolution test was developed to evaluate the release profile of rimonabant from both 20-mg film-coated tablet and capsule dosage forms. The test was applied to compare dissolution profiles of different dosage forms and to evaluate the effect of formulation parameters on the in vitro release profile of the drug. Four different commercially available products were evaluated, and the results obtained show very distinct rates and extent of dissolution among them. The type of excipients used in the capsule formulation significantly influenced the dissolution rate of the formulations studied.
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页码：30 / 36
页数：7
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