Synthesis of Macrocyclic β-Peptidomimetics by Ring-Closing Metathesis

被引：0

作者：

Dinh Hieu Tran ^{[1
]}

Xuan Tu Nguyen ^{[1
]}

Thi Minh Chau Tran ^{[1
]}

Thuy Quynh Le ^{[2
,3
]}

Chang Ho Oh ^{[2
,3
]}

Dinh Hung Mac ^{[1
]}

机构：

[1] VietNam Natl Univ, Fac Chem, Med Chem Lab, 19 Le Thanh Tong, Hanoi 100000, Vietnam

[2] Hanyang Univ, Dept Chem, Seoul 04763, South Korea

[3] Hanyang Univ, Res Inst Nat Sci, Seoul 04763, South Korea

来源：

CHEMISTRYSELECT | 2020年 / 5卷 / 39期

关键词：

beta-amino acid; macrocyclization; metathesis; peptidomimetics; HELICAL SECONDARY STRUCTURE; AMINO-ACIDS; OLEFIN METATHESIS; STAPLED PEPTIDES; LACTAMS; DESIGN;

D O I：

10.1002/slct.202002706

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The synthesis of a series of conformationally constrained peptidomimetics containing a 9-to-13-atom-membered ring by ring-closing metathesis (RCM) is described. The second-generation Grubbs catalyst proved to be the most effective in producing the desired cyclic beta-peptidomimetics with moderate to good yields. Reaction characteristics such as the influence of alkene chain length in the precursors, position of double bond and ring size of products were also discussed.

引用

页码：12232 / 12235

页数：4

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