Asymmetric synthesis of β-hydroxy-α-amino acid

beta-Hydroxy-alpha-amino acids are valuable constituents of complex natural products and medicinally important compounds. For instance, the naturally occurrence beta-hydroxyleucine is a representative of this class and has attracted considerable attention as an unusual amino acid constituent of cyclodepsipeptides such as azinothricin, A 83586 C, papuamides, polyoxypeptins and GE 3. As a consequence of the importance of beta-hydroxy-alpha-amino acids in the biological activities as well as their usefulness as synthetic building blocks, a number of useful strategies have been devised for better method of the synthesis of beta-hydroxy-alpha-amino acids. This review summarizes recent progress in asymmetric synthesis of beta-hydroxy-alpha-amino acids.