Chemical constituents of Swertia yunnanensis and their anti-hepatitis B virus activity

被引：26

作者：

Cao, Tuan-Wu ^{[1
,2
]}

Geng, Chang-An ^{[1
]}

Jiang, Fu-Qiang ^{[1
]}

Ma, Yun-Bao ^{[1
]}

He, Kang ^{[1
]}

Zhou, Ning-Jia ^{[1
,2
]}

Zhang, Xue-Mei ^{[1
]}

Zhou, Jun ^{[1
]}

Chen, Ji-Jun ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100039, Peoples R China

来源：

FITOTERAPIA | 2013年 / 89卷

基金：

中国科学院西部之光基金; 美国国家科学基金会; 中国国家自然科学基金;

关键词：

Swertia yunnanensis; Gentianaceae; Triterpenoids; Sweriyunnanosides A-C; Anti-HBV activity; PENTACYCLIC TRITERPENOIDS;

D O I：

10.1016/j.fitote.2013.05.023

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four new triterpenoids, sweriyunnangenin A (1), sweriyunnanosides A (2), B (3) and C (4), along with nineteen known compounds (5-23) were isolated from Swertia yunnanensis. Based on extensive spectroscopic analyses (1D- and 2D-NMR, HRESIMS, UV, IR, [alpha](D)), the structures of sweriyunnangenin A (1), sweriyunnanosides A (2), B (3) and C (4) were elucidated as taraxer-14-ene-3 alpha,6 beta-diol, oleanolic acid 28-O-beta-D-glucopyranosyl-(1 -> 2)-O-beta-D-glucopyranoside, 2 alpha,3 beta-di-hydroxyolean-12-en-28-oic acid 28-O-beta-D-glucopyranosyl(1 -> 6)-beta-D-glucopyranosyl (1 -> 6)-beta-D-glucopyranosyl(1 -> 2)-beta-D-glucopyranoside and hederagenin 28-O-beta-D-glucopyranosyl (1 -> 6)-beta-D-glucopyranosyl(1 -> 6)-beta-D-glucopyranosyl(1 -> 2)-beta-D-glucopyranoside, respectively. Twenty-two compounds were evaluated for their anti-HBV activities on the HepG 2.2.15 cell line in vitro, of which nine compounds showed potent anti-HBV activities. Compounds 1, 5-6, 14-16 and 19 showed activities against the secretion of HBsAg (IC50 values from 0.10 to 1.76 mM) and HBeAg (IC50 values from 0.04 to 1.41 mM), and compounds 11 and 13-16 exhibited significant inhibition on HBV DNA replication (IC50 values from 0.01 to 0.09 mM). (c) 2013 Elsevier B.V. All rights reserved.

引用

页码：175 / 182

页数：8