Chrysophanol Ameliorate Cerebral Ischemic Injury in Rats by Reducing Inflammatory Response and Oxidative Stress and Improving Energy Metabolism

We investigated the effects of chrysophanol on cerebral ischemic injury in rats and the underlying action mechanism. Fifty-four rats were randomly divided into sham-operated group, model, and treatment groups. The treatment group was administered with 5 mg/kg chrysophanol by gavage for 14 days. The cerebral ischemic injury model was prepared by ligation of bilateral common carotid arteries. After 3 h from modeling, compared with model group, in chrysophanol treatment group the brain index, water content and cerebral infarction percentage were significantly decreased, the brain tissue tumor necrosis factor alpha, interleukin beta and malondialdehyde levels were significantly decreased, the brain tissue superoxide dismutase and glutathione peroxidase levels were significantly increased, the brain tissue lactic acid level was significantly decreased, and the brain tissue Na+-K+-ATPase and Ca2+-ATPase activities were significantly increased. The chrysophanol pre-treatment may ameliorate the cerebral ischemic injury in rats by reducing the inflammatory response and oxidative stress and improving the energy metabolism in brain tissue.