Accumulation of mitochondrial DNA deletions in human retina during aging

被引：2

作者：

Barreau, E ^{[1
]}

Brossas, JY ^{[1
]}

Courtois, Y ^{[1
]}

Treton, JA ^{[1
]}

机构：

[1] INSERM,UNITE RECH DEV VIEILLASSEMENT & PATHOL RETINE,ASSOC CLAUDE BERNARD,CTR RES GERONTOL,F-75016 PARIS,FRANCE

来源：

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE | 1996年 / 37卷 / 02期

关键词：

aging; mitochondrial DNA; neural retina; polymerase chain reaction technique; retinal pigment epithelium;

D O I：

暂无

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose. The authors investigated the presence of mitochondrial DNA (mtDNA) mutations in aging human retina. Methods. A quantitative polymerase chain reaction technique for studying the common mtDNA 4977-deletion (Delta mtDNA(4977)) in retinal pigment epithelium (RPE) and neural retina (NR) was developed. Results. Although no deletion was detected in the fetus, every adult RPE and NR had this common deletion. The ratio of the deleted Delta mtDNA(4977) to the total mtDNA increased significantly in elderly persons 60 to 110 years of age and was greater in peripheral than in central RPE. Conclusions. These results suggest that at least one type of mutation accumulates in the mtDNA in the retina during aging, reflecting a general phenomenon of genomic instability that could influence its function.

引用

页码：384 / 391

页数：8

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