Cyclin-dependent kinase 11 (CDK11) is crucial in the growth of liposarcoma cells

被引：42
|
作者：
Jia, Bin [1 ,2 ,3 ]
Choy, Edwin [1 ,2 ]
Cote, Gregory [1 ,2 ]
Harmon, David [1 ,2 ]
Ye, Shunan [1 ,2 ]
Kan, Quancheng [3 ]
Mankin, Henry [1 ,2 ]
Hornicek, Francis [1 ,2 ]
Duan, Zhenfeng [1 ,2 ]
机构：
[1] Massachusetts Gen Hosp, Ctr Sarcoma & Connect Tissue Oncol, Sarcoma Biol Lab, Boston, MA 02114 USA
[2] Harvard Univ, Sch Med, Boston, MA USA
[3] Zhengzhou Univ, Affiliated Hosp 1, Dept Pharmacol, Zhengzhou 450052, Henan, Peoples R China
来源：
CANCER LETTERS | 2014年 / 342卷 / 01期
基金：
美国国家卫生研究院;
关键词：
Kinase; Liposarcoma; CDK11; Tissue microarray; Immunohistochemistry; ADVANCED SOLID TUMORS; SOFT-TISSUE SARCOMA; I CLINICAL-TRIAL; PHASE-I; DEDIFFERENTIATED LIPOSARCOMA; INHIBITOR FLAVOPIRIDOL; C-JUN; OSTEOSARCOMA; EXPRESSION; COMPLEXES;
D O I：
10.1016/j.canlet.2013.08.040
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Liposarcoma is the second most common soft tissue sarcoma in adults, but treatment options have been quite limited thus far. In this study, we investigated the functional and therapeutic relevance of cyclin-dependent kinase 11 (CDK11) as a putative target in liposarcoma. CDK11 knockdown by synthetic siRNA or lentiviral shRNA decreased cell proliferation, and induced apoptosis in liposarcoma cells. Moreover, CDK11 knockdown enhances the cytotoxic effect of doxorubicin to inhibit cell growth in liposarcoma cells. These findings suggest that CDK11 is critical for the growth and proliferation of liposarcoma cells. CDK11 may be a promising therapeutic target for the treatment of liposarcoma patients. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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页码：104 / 112
页数：9
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