Antidiabetic effects of corosolic acid in KK-Ay diabetic mice

被引：57
|
作者：
Miura, T
Ueda, N
Yamada, K
Fukushima, M
Ishida, T
Kaneko, T
Matsuyama, F
Seino, Y
机构：
[1] Suzuka Univ Med Sci, Dept Clin Nutr, Suzuka, Mie 5100293, Japan
[2] Use Techno Corp Co Ltd, Kyoto 6200055, Japan
[3] Fdn Biomed Res & Innovat, Dept Hlth, Informat Ctr, Chuo Ku, Kobe, Hyogo 6500047, Japan
[4] Suzuka Univ Med Sci, Hitech Res Ctr, Suzuka, Mie 5100293, Japan
[5] Hiroshima Int Univ, Dept Pharmaceut Sci, Hiroshima 7370112, Japan
[6] Kyoto Univ, Dept Metab & Clin Nutr, Fac Med, Sakyo Ku, Kyoto 6060055, Japan
来源：
BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2006年 / 29卷 / 03期
关键词：
corosolic acid; antidiabetic effect; KK-Ay mice; insulin resistance;
D O I：
10.1248/bpb.29.585
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The antidiabetic effects of corosolic acid (CA) were investigated in KK-Ay mice, an animal model of type 2 diabetes. CA (2 mg/kg body weight) reduced the blood glucose levels of KK-Ay mice 4 h after a single oral dose. CA (2 mg/kg) reduced the blood glucose levels in KK-Ay mice 2 weeks after a single oral dose and also significantly lowered plasma insulin levels were in KK-Ay mice under similar conditions. CA-treated KK-Ay mouse blood glucose significantly decreased in an insulin tolerance test. These results support the hypothesis that CA improves glucose metabolism by reducing insulin resistance. Therefore CA may be useful for the treatment of type 2 diabetes.
引用
收藏
页码：585 / 587
页数：3
相关论文
共 50 条
  • [1] Antidiabetic effects of ajoene in genetically diabetic KK-Ay mice
    Hattori, A
    Yamada, N
    Nishikawa, T
    Fukuda, H
    Fujino, T
    JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY, 2005, 51 (05) : 382 - 384
  • [2] Antidiabetic effects of cinnamon oil in diabetic KK-Ay mice
    Ping, Hua
    Zhang, Guijun
    Ren, Guixing
    FOOD AND CHEMICAL TOXICOLOGY, 2010, 48 (8-9) : 2344 - 2349
  • [3] Antidiabetic effect of Nitobegiku in KK-Ay diabetic mice
    Miura, T
    Furuta, K
    Yasuda, A
    Iwamoto, N
    Kato, M
    Ishihara, E
    Ishida, T
    Tanigawa, K
    AMERICAN JOURNAL OF CHINESE MEDICINE, 2002, 30 (01): : 81 - 86
  • [4] Effect of corosolic acid on dietary hypercholesterolemia and hepatic steatosis in KK-Ay diabetic mice
    Takagi, Satoshi
    Miura, Toshihiro
    Ishihara, Eriko
    Ishida, Torao
    Chinzei, Yasuo
    BIOMEDICAL RESEARCH-TOKYO, 2010, 31 (04): : 213 - 218
  • [5] Antidiabetic effect of glycyrrhizin in genetically diabetic KK-Ay mice
    Takii, H
    Kometani, T
    Nishimura, T
    Nakae, T
    Okada, S
    Fushiki, T
    BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2001, 24 (05) : 484 - 487
  • [6] Dietary corosolic acid ameliorates obesity and hepatic steatosis in KK-Ay mice
    Yamada, Kotaro
    Hosokawa, Masaya
    Yamada, Chizumi
    Watanabe, Rie
    Fujimoto, Shimpei
    Fujiwara, Hideya
    Kunitomo, Masaru
    Miura, Toshihiro
    Kaneko, Tetsuo
    Tsuda, Kinsuke
    Seino, Yutaka
    Inagaki, Nobuya
    BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2008, 31 (04) : 651 - 655
  • [7] Diabetic nephropathy in KK and KK-Ay mice
    Okazaki, M
    Saito, Y
    Udaka, Y
    Maruyama, M
    Murakami, H
    Ota, S
    Kikuchi, T
    Oguchi, K
    EXPERIMENTAL ANIMALS, 2002, 51 (02) : 191 - 196
  • [8] Antidiabetic activity of Mung bean extracts in diabetic KK-Ay mice
    Yao, Yang
    Chen, Feng
    Wang, Mingfu
    Wang, Jiashi
    Ren, Guixing
    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2008, 56 (19) : 8869 - 8873
  • [9] Antidiabetic effect of Nitobegiku, the herb Tithonia diversifolia, in KK-Ay diabetic mice
    Miura, T
    Nosaka, K
    Ishii, H
    Ishida, T
    BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2005, 28 (11) : 2152 - 2154
  • [10] Characteristics of Diabetic Osteopenia in KK-Ay Diabetic Mice
    Takagi, Satoshi
    Miura, Toshihiro
    Yamashita, Takenori
    Ando, Naoki
    Nakao, Haruka
    Ishihara, Eriko
    Ishida, Torao
    BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2012, 35 (03) : 438 - 443
12345