The Inhibitory Effects of Representative Chalcones Contained in Angelica keiskei on Melanin Biosynthesis in B16 Melanoma Cells

被引：0

作者：

Arung, Enos Tangke ^{[2
]}

Furuta, Shoko ^{[1
]}

Sugamoto, Kazuhiro ^{[3
]}

Shimizu, Kuniyoshi ^{[1
]}

Ishikawa, Hiroya ^{[4
]}

Matsushita, Yoh-ichi ^{[3
]}

Kondo, Ryuichiro ^{[1
]}

机构：

[1] Kyushu Univ, Fac Agr, Dept Agroenvironm Sci, Fukuoka 8128581, Japan

[2] Mulawarman Univ, Fac Forestry, Dept Forest Prod Technol, Samarinda 75123, Indonesia

[3] Miyazaki Univ, Fac Engn, Dept Appl Chem, Miyazaki 8892192, Japan

[4] Fukuoka Womens Univ, Fac Human Environm Sci, Dept Nutr & Hlth Sci, Fukuoka 8138529, Japan

来源：

NATURAL PRODUCT COMMUNICATIONS | 2012年 / 7卷 / 08期

基金：

日本学术振兴会;

关键词：

Chalcones; Angelica keiskei; B16 melanoma cells; Melanin inhibition; ARTOCARPUS-HETEROPHYLLUS; TYROSINASE; MELANOCYTES; APOPTOSIS; MECHANISM; PRENYL;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In our effort to find new whitening agents, we evaluated the effects of representative chalcones [4-hydroxyderricin (1), xanthoangelol (2), xanthoangelol H (3), deoxyxanthoangelol H (4), and deoxydihydroxanthoangelol H (5)] contained in the stem of Angelica keiskei on tyrosinase and melanin formation in B16 melanoma cells. In addition, the antioxidant effects of these chalcones in ORAC and DPPH assays were also determined. Interestingly, all chalcones (1-5) inhibit melanin formation in B16 melanoma cells, with low cytotoxicity.

引用

页码：1007 / 1010

页数：4

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