Ontogenic changes in human placental sodium iodide symporter expression

被引：11
|
作者：
Li, H. [1 ]
Patel, J. [2 ]
Mortimer, R. H. [1 ,2 ,3 ]
Richard, K. [1 ,2 ]
机构：
[1] Royal Brisbane & Womens Hosp, Conjoint Endocrine Lab, Brisbane, Qld 4029, Australia
[2] Univ Queensland, Sch Med, Brisbane, Qld 4006, Australia
[3] Univ Queensland, Disciplines Med Obstet & Gynaecol, Herston, Qld 4006, Australia
来源：
PLACENTA | 2012年 / 33卷 / 11期
关键词：
Placenta; Iodide transport; Ontogeny; Sodium/iodide symporter; OXYGEN CONCENTRATIONS; CELLS; MECHANISMS; NIS;
D O I：
10.1016/j.placenta.2012.08.002
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The human fetus requires a maternal supply of iodide to synthesize thyroid hormone from 16 weeks gestation. Placental iodide transport is regulated by the sodium iodide symporter (NIS). We studied the ontogeny of NIS in placentas from surgically terminated pregnancies and from normal term pregnancies. NIS mRNA was low at 6 weeks gestation and peaked at 12 weeks gestation. Placental NIS protein levels are significantly correlated with gestational age during early pregnancy and increase with increased placental vascularization. This would lead to increased iodide supply to meet increased fetal requirements for thyroid hormone synthesis as the pregnancy progresses. Crown Copyright (c) 2012 Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：946 / 948
页数：3
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