Transforming Epidemiology for 21st Century Medicine and Public Health

被引：78
|
作者：
Khoury, Muin J. [1 ,5 ]
Lam, Tram Kim [1 ]
Ioannidis, John P. A. [6 ,7 ]
Hartge, Patricia [2 ]
Spitz, Margaret R. [8 ]
Buring, Julie E. [9 ]
Chanock, Stephen J. [2 ]
Croyle, Robert T. [1 ]
Goddard, Katrina A. [13 ]
Ginsburg, Geoffrey S. [14 ]
Herceg, Zdenko [15 ]
Hiatt, Robert A. [16 ]
Hoover, Robert N. [2 ]
Hunter, David J. [11 ]
Kramer, Barnet S. [3 ]
Lauer, Michael S. [4 ]
Meyerhardt, Jeffrey A. [10 ]
Olopade, Olufunmilayo I. [17 ]
Palmer, Julie R. [12 ]
Sellers, Thomas A. [18 ]
Seminara, Daniela [1 ]
Ransohoff, David F. [19 ,20 ]
Rebbeck, Timothy R. [21 ,22 ]
Tourassi, Georgia [23 ]
Winn, Deborah M. [1 ]
Zauber, Ann [24 ]
Schully, Sheri D. [1 ]
机构：
[1] NCI, Div Canc Control & Populat Sci, NIH, Bethesda, MD 20892 USA
[2] NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA
[3] NCI, Div Canc Prevent, NIH, Bethesda, MD 20892 USA
[4] NHLBI, Div Cardiovasc Sci, NIH, Bethesda, MD 20892 USA
[5] Ctr Dis Control & Prevent, Off Publ Hlth Genom, Atlanta, GA 30333 USA
[6] Stanford Univ, Dept Med, Stanford Prevent Res Ctr, Dept Hlth Res & Policy,Sch Med, Stanford, CA 94305 USA
[7] Stanford Univ, Dept Stat, Sch Humanities & Sci, Stanford, CA 94305 USA
[8] Baylor Coll Med, Dan L Duncan Canc Ctr, Houston, TX 77030 USA
[9] Brigham & Womens Hosp, Div Med, Boston, MA 02115 USA
[10] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Med Oncol, Cambridge, MA 02138 USA
[11] Harvard Univ, Sch Publ Hlth, Dept Epidemiol & Nutr, Cambridge, MA 02138 USA
[12] Boston Univ, Slone Epidemiol Ctr, Boston, MA 02215 USA
[13] Kaiser Permanente, Ctr Hlth Res, Portland, OR USA
[14] Duke Univ, Sch Med, Ctr Genom Med, Inst Genome Sci & Policy, Durham, NC USA
[15] Int Agcy Res Canc, F-69372 Lyon, France
[16] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA
[17] Univ Chicago Med, Dept Med, Ctr Clin Canc Genet & Global Hlth, Chicago, IL USA
[18] Univ S Florida, H Lee Moffitt Canc Ctr, Off Director, Tampa, FL 33682 USA
[19] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA
[20] Univ N Carolina, Dept Med, Chapel Hill, NC USA
[21] Univ Penn, Perelman Sch Med, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA
[22] Univ Penn, Perelman Sch Med, Abramson Canc Ctr, Philadelphia, PA 19104 USA
[23] Oak Ridge Natl Lab, Computat Sci & Engn Div, Oak Ridge, TN USA
[24] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10021 USA
来源：
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION | 2013年 / 22卷 / 04期
关键词：
CANCER-EPIDEMIOLOGY; KNOWLEDGE INTEGRATION; OPPORTUNITIES; THINKING; LESSONS; SCIENCE; FUTURE; OMICS; TEAM; TIME;
D O I：
10.1158/1055-9965.EPI-13-0146
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In 2012, the National Cancer Institute (NCI) engaged the scientific community to provide a vision for cancer epidemiology in the 21st century. Eight overarching thematic recommendations, with proposed corresponding actions for consideration by funding agencies, professional societies, and the research community emerged from the collective intellectual discourse. The themes are (i) extending the reach of epidemiology beyond discovery and etiologic research to include multilevel analysis, intervention evaluation, implementation, and outcomes research; (ii) transforming the practice of epidemiology by moving toward more access and sharing of protocols, data, metadata, and specimens to foster collaboration, to ensure reproducibility and replication, and accelerate translation; (iii) expanding cohort studies to collect exposure, clinical, and other information across the life course and examining multiple health-related endpoints; (iv) developing and validating reliable methods and technologies to quantify exposures and outcomes on a massive scale, and to assess concomitantly the role of multiple factors in complex diseases; (v) integrating "big data" science into the practice of epidemiology; (vi) expanding knowledge integration to drive research, policy, and practice; (vii) transforming training of 21st century epidemiologists to address interdisciplinary and translational research; and (viii) optimizing the use of resources and infrastructure for epidemiologic studies. These recommendations can transform cancer epidemiology and the field of epidemiology, in general, by enhancing transparency, interdisciplinary collaboration, and strategic applications of new technologies. They should lay a strong scientific foundation for accelerated translation of scientific discoveries into individual and population health benefits. Cancer Epidemiol Biomarkers Prev; 22(4); 508-16. (c) 2013 AACR.
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页码：508 / 516
页数：9
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