Graphene-Sealed Flow Cells for In Situ Transmission Electron Microscopy of Liquid Samples

被引：38
|
作者：
Dunn, Gabriel [1 ,2 ,3 ,4 ]
Adiga, Vivekananda P. [1 ,2 ,3 ,4 ]
Thang Pham [1 ,3 ,4 ]
Bryant, Christopher [1 ,2 ,3 ,4 ]
Horton-Bailey, Donez J. [1 ,2 ,3 ,4 ]
Belling, Jason N. [1 ]
LaFrance, Ben [5 ]
Jackson, Jonathan A. [1 ]
Barzegar, Hamid Reza [1 ,2 ,3 ,4 ]
Yuk, Jong Min [1 ,2 ,3 ,4 ]
Aloni, Shaul [6 ]
Crommie, Michael F. [1 ,3 ,4 ]
Zettl, Alex [1 ,2 ,3 ,4 ]
机构：
[1] Univ Calif Berkeley, Dept Phys, Berkeley, CA 94720 USA
[2] Lawrence Berkeley Natl Lab, Mat Sci Div, Berkeley, CA 94720 USA
[3] Univ Calif Berkeley, Kavli Energy NanoSci Inst, Berkeley, CA 94720 USA
[4] Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA
[5] Univ Calif Berkeley, Dept Biochem & Mol Biol, Berkeley, CA 94720 USA
[6] Lawrence Berkeley Natl Lab, Mol Foundry, Berkeley, CA 94720 USA
来源：
ACS NANO | 2020年 / 14卷 / 08期
基金：
美国国家科学基金会;
关键词：
graphene liquid cells; liquid cell transmission electron microscopy; flow cells; resolution; nanofluidic channel; RESOLUTION; GROWTH;
D O I：
10.1021/acsnano.0c00431
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We introduce a graphene-based nanofluidic cell that facilitates in situ imaging of liquid samples via transmission electron microscopy. The cell combines the benefits of graphene liquid cells-namely, high resolution, reduced charging effects, and excellent sample stability-with the ability to introduce reactants and control fluid concentrations as provided by conventional silicon-nitride-windowed flow cells. The graphene flow cell offers significantly less window bowing compared to existing commercial holders. We demonstrate the performance of the flow cell by imaging gold nanoparticle dynamics and uranyl acetate crystallization. Our results confirm the utility of graphene flow cells in obtaining the high spatial and temporal resolution required for probing the complex dynamics of nanoparticles and nucleation pathways in aqueous solutions.
引用
收藏
页码：9637 / 9643
页数：7
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