Drug-induced lupus and autoimmune hepatitis secondary to infliximab for psoriasis

被引：27
|
作者：
Dang, Lucy J. [1 ,3 ]
Lubel, John S. [2 ,3 ]
Gunatheesan, Shyamalar [1 ]
Hosking, Patrick [4 ]
Su, John [1 ,3 ,5 ]
机构：
[1] Monash Univ, Dept Dermatol, Melbourne, Vic 3004, Australia
[2] Monash Univ, Box Hill Hosp, Melbourne, Vic 3004, Australia
[3] Monash Univ, Eastern Hlth Clin Sch, Melbourne, Vic 3004, Australia
[4] Univ Melbourne, Melbourne, Vic, Australia
[5] Univ Melbourne, Dept Paediat, Melbourne, Vic, Australia
来源：
AUSTRALASIAN JOURNAL OF DERMATOLOGY | 2014年 / 55卷 / 01期
关键词：
adverse drug reaction; dermatology; gastroenterology; hepatitis; psoriasis; THERAPY; AUTOANTIBODIES; ARTHRITIS;
D O I：
10.1111/ajd.12054
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
We describe a case of previously unreported autoimmune hepatitis and lupus-like syndrome induced by infliximab treatment for chronic plaque psoriasis. The condition resolved after withdrawal of infliximab, with the liver injury having been reversed and minimal periportal fibrosis. In a two-part discussion we review the current literature on the pharmacology of infliximab and provide recommendations for management of infliximab side effects.
引用
收藏
页码：75 / 79
页数：5
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