Towards rapid DNA sequencing: Detecting single-stranded DNA with a solid-state nanopore

被引：15
|
作者：
Yan, H [1 ]
Xu, BQ
机构：
[1] Arizona State Univ, Dept Chem & Biochem, Biodesign Inst, Tempe, AZ 85287 USA
[2] Univ Georgia, Dept Biol & Agr Engn, Athens, GA 30602 USA
来源：
SMALL | 2006年 / 2卷 / 03期
关键词：
DNA; sequencing; single-molecute detection; nanopores;
D O I：
10.1002/smll.200500464
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Nanopores are used for rapid detection of single DNA molecules and their sequences. Two types of nanopores were used for this purpose such as, nanopores embedded in an insulating membrane or solid state nanopores and SiO2. Solid state nanopores are chemically, thermally, and mechanically stable, which makes it possible to denature DNA under conditions of high pH and increased temperature. It is possible to incorporate solid-state nanopores with local and optical probes to form an integrated circuit.
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页码：310 / 312
页数：3
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