Tumoral fibrosis effect on the radiation absorbed dose of 177Lu-Tyr3-octreotate and 177Lu-Tyr3-octreotate conjugated to gold nanoparticles

被引：6
|
作者：
Azorin-Vega, E. P. [1 ]
Zambrano-Ramirez, O. D. [1 ,3 ]
Rojas-Calderon, E. L. [2 ]
Ocampo-Garcia, B. E. [1 ]
Ferro-Flores, G. [1 ]
机构：
[1] Salud & Inst Nacl Invest Nucl, Gerencia Aplicac Nucl, Ocoyoacac 52750, Estado De Mexic, Mexico
[2] Inst Nacl Invest Nucl, Gerencia Ciencias Ambient, Ocoyoacac 52750, Estado De Mexic, Mexico
[3] Inst Politecn Nacl, Escuela Super Fis & Matemat, Mexico City 07738, DF, Mexico
来源：
APPLIED RADIATION AND ISOTOPES | 2015年 / 100卷
关键词：
Tumoral fibrosis model; Monte Carlo; Targeted radiotherapy; Gold nanoparticles; Lutetium-177; Octreotate; CANCER; SOMATOSTATIN; THERAPY;
D O I：
10.1016/j.apradiso.2014.09.005
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The aim of this work was to evaluate the tumoral fibrosis effect on the radiation absorbed dose of the radiopharmaceuticals Lu-177-Tyr(3)-octreotate (monomeric) and Lu-177-Tyr(3)-octreotate-gold nanoparticles (multimeric) using an experimental HeLa cells tumoral model and the Monte Carlo PENELOPE code. Experimental and computer micro-environment models with or without fibrosis were constructed. Results showed that fibrosis increases up to 33% the tumor radiation absorbed dose, although the major effect on the dose was produced by the type of radiopharmaceutical (112 Gy-multimeric vs. 43 Gy-monomeric). (C) 2014 Elsevier Ltd. All rights reserved.
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页码：96 / 100
页数：5
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