Thiazolidinediones and Fertility in Polycystic Ovary Syndrome (PCOS)

被引：45
|
作者：
Froment, Pascal [1 ]
Touraine, Philippe [2 ]
机构：
[1] Hop Debrousse, UMR Commun Cellulaire & Differenciat, INSERM, Unite 418, F-69322 Lyon, France
[2] GH Pitie Salpetriere, Dept Endocrinol & Reprod Med, F-75651 Paris 13, France
来源：
PPAR RESEARCH | 2006年 / 2006卷
关键词：
D O I：
10.1155/PPAR/2006/73986
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Polycystic ovary syndrome (PCOS) is the most frequent cause of female infertility. The treatment of PCOS patients with insulin sensitizers, such as metformin or thiazolidinediones, increases the ovulation rate and the number of successful pregnancies. The positive action of the insulin-sensitizing treatments could be explained by a decrease in the peripheral insulin resistance but also by a direct action at the ovarian level. We report in this review different hypotheses of thiazolidinediones actions to improve PCOS (steroid secretion by ovarian cells; insulin sensitivity in muscle and adipocyte and fat redistribution). Copyright (C) 2006 P. Froment and P. Touraine.
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页数：8
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