Fluoride as an inducible DNA cross-linking agent for new antitumor prodrug

被引：15

作者：

Wu, Jun ^{[1
]}

Huang, Rong ^{[1
]}

Wang, Tianlu ^{[1
]}

Zhao, Xi ^{[1
]}

Zhang, Wanyi ^{[1
]}

Weng, Xiaocheng ^{[1
]}

Tian, Tian ^{[1
]}

Zhou, Xiang ^{[1
,2
]}

机构：

[1] Wuhan Univ, Coll Chem & Mol Sci, Key Lab Biomed Polymers, Minist Educ,State Key Lab Virol, Wuhan 430072, Hubei, Peoples R China

[2] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100871, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2013年 / 11卷 / 14期

关键词：

QUINONE METHIDES; DEOXYGUANOSINE RESIDUES; DUPLEX DNA; CANCER; CHLORAMBUCIL; NANOPARTICLES; ALKYLATION; REACTIVITY; RESISTANCE; DELIVERY;

D O I：

10.1039/c2ob27324a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two new small compounds, which undergo fluoride-mediated self rearrangement, produce active DNA alkylating agent nitrogen mustard leading to DNA damage and finally cell death, providing potential antitumor prodrugs.

引用

页码：2365 / 2369

页数：5

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