Elevated nocturnal and morning blood pressure in patients with obstructive sleep apnea syndrome

被引：15

作者：

He Quan-ying ^{[2
]}

Feng Jing ^{[1
]}

Zhang Xi-long ^{[3
]}

Liang Zong-an ^{[4
]}

Huang Shao-guang ^{[5
]}

Kang Jian ^{[6
]}

Wang Guang-fa ^{[7
]}

Zhang Li-qiang ^{[8
]}

Ma Li-jun ^{[9
]}

Wang Bei ^{[10
]}

Lin Qi-chang ^{[11
]}

Zhang Jin-nong ^{[12
]}

Liu Hui-guo ^{[13
]}

Luo Yuan-ming ^{[14
]}

Liu Jian-hong ^{[15
]}

Wang Shi ^{[16
]}

Xiao Gao-hui ^{[17
]}

Lu Gan ^{[18
]}

Zhang Jin ^{[19
]}

Feng Xue-wei ^{[20
]}

Chen Bao-yuan ^{[1
]}

机构：

[1] Tianjin Med Univ, Dept Resp Dis, Gen Hosp, Tianjin 300052, Peoples R China

[2] Peking Univ, Peoples Hosp, Dept Resp Dis, Beijing 100044, Peoples R China

[3] Nanjing Med Univ, Affiliated Hosp 1, Dept Resp Dis, Nanjing 210029, Jiangsu, Peoples R China

[4] Sichuan Univ, W China Hosp, Dept Resp Dis, Chengdu 610041, Sichuan, Peoples R China

[5] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Resp Dis, Shanghai 200025, Peoples R China

[6] China Med Univ, Affiliated Hosp 1, Dept Resp Dis, Shenyang 110001, Liaoning, Peoples R China

[7] Peking Univ, Hosp 1, Dept Resp Dis, Beijing 100034, Peoples R China

[8] Peking Univ, Hosp 3, Dept Resp Dis, Beijing 100191, Peoples R China

[9] Henan Prov Peoples Hosp, Dept Resp Dis, Zhengzhou 450003, Henan, Peoples R China

[10] Shanxi Med Univ, Affiliated Hosp 2, Dept Resp Dis, Taiyuan 030001, Shanxi, Peoples R China

[11] Fujian Med Univ, Affiliated Hosp 1, Dept Resp Dis, Fuzhou 350005, Fujian, Peoples R China

[12] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Resp Dis, Wuhan 430022, Hubei, Peoples R China

[13] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Resp Dis, Wuhan 430030, Hubei, Peoples R China

[14] Guangzhou Med Univ, Affiliated Hosp 1, Guangzhou Inst Resp Dis, Guangzhou 510120, Guangdong, Peoples R China

[15] Guangxi Zhuang Autonomous Reg Peoples Hosp, Dept Resp Dis, Nanning 530021, Guangxi, Peoples R China

[16] Shenyang Med Coll, Cent Hosp, Dept Resp Dis, Shenyang 110024, Liaoning, Peoples R China

[17] Beijing Gongan Hosp, Dept Resp Dis, Beijing 100006, Peoples R China

[18] Jiangsu Senil Hosp, Dept Resp Dis, Nanjing 210024, Jiangsu, Peoples R China

[19] Ningxia Med Coll, Affiliated Hosp, Dept Resp Dis, Yinchuan 750004, Ningxia, Peoples R China

[20] China Med Univ, Affiliated Hosp 2, Dept Resp Dis, Shenyang 110004, Liaoning, Peoples R China

来源：

CHINESE MEDICAL JOURNAL | 2012年 / 125卷 / 10期

基金：

中国国家自然科学基金;

关键词：

obstructive sleep apnea syndrome; blood pressure; hypertension; dipping; polysomnography; apnea-hypopnea index; HYPERTENSION; ASSOCIATION; PREVALENCE; RISK; MULTICENTER; MECHANISMS; INSOMNIA; TIME;

D O I：

10.3760/cma.j.issn.0366-6999.2012.10.011

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background The nocturnal nondipping and elevated morning blood pressure (BP) in patients with obstructive sleep apnea syndrome (OSAS) have not yet been well investigated in Chinese patients. This study aimed to describe the BP profile, and to elucidate the relationships between daytime BP and nighttime BP, and between evening BP and morning BP in patients with OSAS. Methods Twenty teaching hospital sleep centers in China were organized by the Chinese Medical Association to participate in this study and 2297 patients were recruited between January 2004 and April 2006. BP assessments were made at four time points (daytime, evening, nighttime and morning) and polysomnography (PSG) was performed and subjects were classified into four groups by their apnea-hypopnea index (AHI): control, n=213 with AHI <5; mild, n=420 with AHI >= 5 and <15; moderate, n=460 with AHI >= 15 and <30; and severe, n=1204 with AHI SPSS 11.5 software package was used for statistical analysis and figure drawing. Results All the average daytime, nighttime, evening and morning BPs were positively correlated with AHI and negatively correlated with nadir nocturnal oxygen saturation. The ratios of nighttime/daytime and morning/evening average BP were positively correlated with AHI. The ratio of nighttime/daytime systolic BP became a "reversed BP dipping" pattern until the classification reached severe, while the ratio of nighttime/daytime diastolic BP became reversed at moderate. Similarly, the ratio of morning/evening diastolic BP becomes reversed even at mild. Conclusions OSAS may result in higher BP levels at all four time points. The ratios of nighttime/daytime and morning/evening BP increase with increased AHI. The increasing of diastolic BP, which is inclined to rise more quickly, is not parallel with increasing systolic BP. Chin Med J 2012;125(10):1740-1746

引用

页码：1740 / 1746

页数：7

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[1] Elevated nocturnal and morning blood pressure in patients with obstructive sleep apnea syndrome
HE QuanyingFENG JingZHANG XilongLIANG ZonganHUANG ShaoguangKANG JianWANG Guangfa ZHANG LiqiangMA LijunWANG BeiLIN QichangZHANG JinnongLIU HuiguoLUO Yuanming LIU JianhongWANG ShiXIAO GaohuiLU GanZHANG JinFENG Xuewei CHEN Baoyuan
Sleep Breath Disorder GroupSociety of Respiratory MedicineChinese Medical Association Department of Respiratory DiseasesPeking University Peoples HospitalBeijing China Department of Respiratory DiseasesTianjin Medical University General HospitalTianjin China Department of Respiratory DiseasesFirst Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu China Department of Respiratory DiseasesWest China HospitalSichuan UniversityChengduSichuan China Department of Respiratory DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai China Department of Respiratory DiseasesFirst Affiliated Hospital of China Medical UniversityShenyangLiaoning China Department of Respiratory DiseasesPeking University First HospitalBeijing China Department of Respiratory DiseasesPeking University Third HospitalBeijing China Department of Respiratory DiseasesHenan Provincial Peoples HospitalZhengzhouHenan China Department of Respiratory DiseasesSecond Affiliated Hospital of Shanxi Medical UniversityTaiyuanShanxi China Department of Respiratory DiseasesFirst Affiliated Hospital of Fujian Medical UniversityFuzhouFujian China Department of Respiratory DiseasesUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan Hubei China Department of Respiratory DiseasesTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan Hubei China Guangzhou Institute of Respiratory DiseaseFirst Affiliated Hospital of Guangzhou Medical CollegeGuangzhouGuangdong China Department of Respiratory DiseasesGuangxi Zhuang Autonomous Region Peoples HospitalNanningGuangxi China Department of Respiratory DiseasesCentral Hospital of Shenyang Medical CollegeShenyangLiaoning China Department of Respiratory DiseasesBeijing Gongan HospitalBeijing China Department of Respiratory DiseasesJiangsu Senility HospitalNanjingJiangsu China Department of Respiratory DiseasesAffiliated Hospital of Ningxia Medical CollegeYinchuanNingxia China Department of Respiratory DiseasesSecond Affiliated Hospital of China Medical UniversityShenyangLiaoning China
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