Au nanoparticle-based sensor for apomorphine detection in plasma

被引：11
|
作者：
Zanchi, Chiara [1 ]
Lucotti, Andrea [2 ]
Tommasini, Matteo [2 ]
Trusso, Sebastiano [3 ]
de Grazia, Ugo [4 ]
Ciusani, Emilio [4 ]
Ossi, Paolo M. [1 ]
机构：
[1] Politecn Milan, Dipartimento Energia, I-20133 Milan, Italy
[2] Politecn Milan, Dipartimento Chim Mat & Ingn Chim Giulio Natta, I-20133 Milan, Italy
[3] CNR, IPCF, I-98158 Messina, Italy
[4] Fdn IRCCS Ist Neurol Carlo Besta, Lab Patol Clin & Genet Med, I-20133 Milan, Italy
来源：
BEILSTEIN JOURNAL OF NANOTECHNOLOGY | 2015年 / 6卷
关键词：
apomorphine; Au NPs; nano-roughened films; pulsed laser deposition; self-assembled films; SERS; ENHANCED RAMAN-SPECTROSCOPY; SCATTERING; SERS; MOLECULES; ABLATION; GROWTH; AG;
D O I：
10.3762/bjnano.6.228
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Artificially roughened gold surfaces with controlled nanostructure produced by pulsed laser deposition have been investigated as sensors for apomorphine detection aiming at clinical application. The use of such gold surfaces has been optimized using aqueous solutions of apomorphine in the concentration range between 3.3 x 10(-4) M and 3.3 x 10(-7) M. The experimental parameters have been investigated and the dynamic concentration range of the sensor has been assessed by the selection of two apomorphine surface enhanced Raman scattering (SERS) peaks. The sensor behavior used to detect apomorphine in unfiltered human blood plasma is presented and discussed.
引用
收藏
页码：2224 / 2232
页数：9
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