Long non-coding RNA SPRY4-IT1 promotes gallbladder carcinoma progression

被引：17
|
作者：
Yang, Liang [1 ]
Cheng, Xi [1 ]
Ge, Naijian [2 ]
Guo, Weixing [3 ]
Feng, Feiling [4 ]
Wan, Fuying [1 ]
机构：
[1] Second Mil Med Univ, East Hepatobiliary Surg Hosp, Ctr Radiat, Shanghai 201805, Peoples R China
[2] Second Mil Med Univ, Eastern Hepatobiliary Surg Hosp, Mini Invas Intervent Ctr, Shanghai 200438, Peoples R China
[3] Second Mil Med Univ, Eastern Hepatobiliary Surg Hosp, Hepat Surg Dept 6, Shanghai 200438, Peoples R China
[4] Second Mil Med Univ, Eastern Hepatobiliary Surg Hosp, Dept Biliary Tract, Shanghai 200438, Peoples R China
来源：
ONCOTARGET | 2017年 / 8卷 / 02期
关键词：
SPRY4-IT1; LncRNA; GBC; metastasis; EMT; EPITHELIAL-MESENCHYMAL TRANSITION; POOR-PROGNOSIS; CELL CARCINOMA; GASTRIC-CANCER; METASTASIS; TARGETS; DISEASE;
D O I：
10.18632/oncotarget.13621
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Gallbladder carcinoma (GBC) is the most common malignancy of the bile duct and patients with GBC have extremely poor prognoses. Long non-coding RNAs (lncRNAs) are found to be dysregulated in a variety of cancers, including GBC. SPRY4-IT1 has been recently revealed as oncogenic regulator in many cancers. However, whether SPRY4-IT1 is involved in GBC progression remains largely unknown. To investigate the role of SPRY4-IT1 in GBC, we evaluated the expression SPRY4-IT1 in GBC tissues and cell lines, and investigated the effect of SPRY4-IT1 knockdown on cell proliferation, migration and invasion of GBC in vitro. Our result showed that SPRY4-IT1 was upregulated in GBC tissues. Further experiments revealed that SPRY4-IT1 knockdown significantly inhibited GBC cell proliferation. Furthermore, inhibitory effects of SPRY4-IT1 on cell migration and invasion were partly associated with EMT process. In conclusion, these data suggest that SPRY4-IT1 could be an oncogene for GBC, and may be served as a candidate target for new therapies in human GBC.
引用
收藏
页码：3104 / 3110
页数：7
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