Pectin: A Long-Neglected Broad-Spectrum Antibacterial

被引:70
|
作者
Ciriminna, Rosaria [1 ]
Fidalgo, Alexandra [2 ,3 ]
Meneguzzo, Francesco [4 ]
Presentato, Alessandro [5 ]
Scurria, Antonino [1 ]
Nuzzo, Domenico [6 ]
Alduina, Rosa [5 ]
Ilharco, Laura M. [2 ,3 ]
Pagliaro, Mario [1 ]
机构
[1] CNR, Ist Studio Mat Nanostrutturati, Via U La Malfa 153, I-90146 Palermo, Italy
[2] Univ Lisbon, Inst Super Tecn, Ctr Quim Fis Mol, Av Rovisco Pais 1, P-1049001 Lisbon, Portugal
[3] Univ Lisbon, Inst Super Tecn, IN Inst Nanosci & Nanotechnol, Av Rovisco Pais 1, P-1049001 Lisbon, Portugal
[4] Ist Bioecon, Via Madonna Piano 10, I-50019 Sesto Fiorentino, Italy
[5] Univ Palermo, Dept Biol Chem & Pharmaceut Sci & Technol, I-90028 Palermo, Italy
[6] CNR, Ist Ric & Innovaz Biomed, Via U La Malfa 153, I-90146 Palermo, Italy
关键词
antibacterial agents; antimicrobial agents; citrus pectin; pectin; polysaccharides; ANTIMICROBIAL ACTION; CITRUS PECTIN; EXTRACTION; ORANGE; AGENT;
D O I
10.1002/cmdc.202000518
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
First reported in the late 1930s and partly explained in 1970, the antibacterial activity of pectin remained almost ignored until the late 1990s. The concomitant emergence of research on natural antibacterials and new usages of pectin polysaccharides, including those in medicine widely researched in Russia, has led to a renaissance of research into the physiological properties of this uniquely versatile polysaccharide ubiquitous in plants and fruits. By collecting scattered information, this study provides an updated overview of the subtle factors affecting the behaviour of pectin as an antimicrobial. Less-degraded pectin extracted by acid-free routes, we argue in the conclusions, will soon find applications from new treatments for polymicrobial infections to use as an implantable biomaterial in tissue and bone engineering.
引用
收藏
页码:2228 / 2235
页数:8
相关论文
共 50 条
  • [1] Repurposing ethyl bromopyruvate as a broad-spectrum antibacterial
    Kumar, Ajay
    Boradia, Vishant Mahendra
    Thakare, Ritesh
    Singh, Alok Kumar
    Gani, Zahid
    Das, Swetarka
    Patidar, Anil
    Dasgupta, Arunava
    Chopra, Sidharth
    Raje, Manoj
    Raje, Chaaya Iyengar
    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2019, 74 (04) : 912 - 920
  • [2] Broad-spectrum antibacterial properties of Thymus fallax
    Ozturk, S
    Ercisli, S
    PHARMACEUTICAL BIOLOGY, 2005, 43 (07) : 609 - 613
  • [3] CIPROFLOXACIN - A NEW BROAD-SPECTRUM ANTIBACTERIAL AGENT
    不详
    PRACTITIONER, 1987, 231 (1429) : 641 - &
  • [4] Aryl urea analogs with broad-spectrum antibacterial activity
    Seth, PP
    Ranken, R
    Robinson, DE
    Osgood, SA
    Risen, LA
    Rodgers, EL
    Migawa, MT
    Jefferson, EA
    Swayze, EE
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (22) : 5569 - 5572
  • [5] Effect of Shufeng Jiedu capsules as a broad-spectrum antibacterial
    Bao, Yanyan
    Gao, Yingjie
    Cui, Xiaolan
    BIOSCIENCE TRENDS, 2016, 10 (01) : 74 - 78
  • [6] MICONAZOLE, A BROAD-SPECTRUM ANTIMYCOTIC AGENT WITH ANTIBACTERIAL ACTIVITY
    VANCUTSEM, JM
    THIENPONT, D
    CHEMOTHERAPY, 1972, 17 (06) : 392 - +
  • [7] Kibdelomycin Is a Bactericidal Broad-Spectrum Aerobic Antibacterial Agent
    Singh, Sheo B.
    Dayananth, Priya
    Balibar, Carl J.
    Garlisi, Charles G.
    Lu, Jun
    Kishii, Ryuta
    Takei, Masaya
    Fukuda, Yasumichi
    Ha, Sookhee
    Young, Katherine
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2015, 59 (06) : 3474 - 3481
  • [8] A Nanocomposite Hydrogel with Potent and Broad-Spectrum Antibacterial Activity
    Dai, Tianjiao
    Wang, Changping
    Wang, Yuqing
    Xu, Wei
    Hu, Jingjing
    Cheng, Yiyun
    ACS APPLIED MATERIALS & INTERFACES, 2018, 10 (17) : 15163 - 15173
  • [10] Degradable Carbon Dots with Broad-Spectrum Antibacterial Activity
    Li, Hao
    Huang, Jian
    Song, Yuxiang
    Zhang, Mengling
    Wang, Huibo
    Lu, Fang
    Huang, Hui
    Liu, Yang
    Dai, Xing
    Gu, Zonglin
    Yang, Zaixing
    Zhou, Ruhong
    Kang, Zhenhui
    ACS APPLIED MATERIALS & INTERFACES, 2018, 10 (32) : 26936 - 26946