Glucanase Induces Filamentation of the Fungal Pathogen Candida albicans

被引：17
|
作者：
Xu, Hongbin [1 ]
Nobile, Clarissa J. [2 ]
Dongari-Bagtzoglou, Anna [1 ]
机构：
[1] Univ Connecticut, Ctr Hlth, Dept Oral Hlth & Diagnost Sci, Farmington, CT 06030 USA
[2] Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA
来源：
PLOS ONE | 2013年 / 8卷 / 05期
关键词：
GERM-TUBE FORMATION; MOLECULAR-CLONING; O-MANNOSYLATION; GENE; MORPHOGENESIS; INDUCTION; PATHWAY; GROWTH;
D O I：
10.1371/journal.pone.0063736
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Candida albicans is the most common human fungal pathogen. Many organisms, including C. albicans, secrete glucanases under different environmental conditions. Here, we report a novel role for beta-1, 3-glucanase in inducing Candida albicans to form filaments at 22 degrees C and enhancing filamentation at 37 degrees C in nutrient-rich medium. Quorum sensing, the efg1-signaling and cek1 MAP kinase pathways are involved in this process. Our data suggest that the natural antifungal agent beta-glucanase may support morphologic transformation of Candida albicans at a wide range of ambient temperatures.
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页数：7
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