Why is pancreatic cancer so deadly? The pathologist's view

被引：75

作者：

Hruban, Ralph H. ^{[1
]}

Gaida, Matthias M. ^{[2
]}

Thompson, Elizabeth ^{[1
]}

Hong, Seung-Mo ^{[1
,3
]}

Noe, Michael ^{[1
]}

Brosens, Lodewijk A. A. ^{[4
,5
]}

Jongepier, Martine ^{[4
]}

Offerhaus, G. Johan A. ^{[4
]}

Wood, Laura D. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Pathol, Sol Goldman Pancreat Canc Res Ctr, Carnegie Room 415,600 North Wolfe St, Baltimore, MD 21287 USA

[2] Univ Hosp Heidelberg, Dept Gen Pathol, Heidelberg, Germany

[3] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Pathol, Seoul, South Korea

[4] Univ Med Ctr Utrecht, Dept Pathol, Utrecht, Netherlands

[5] Radboud Univ Nijmegen, Med Ctr, Dept Pathol, Nijmegen, Netherlands

来源：

JOURNAL OF PATHOLOGY | 2019年 / 248卷 / 02期

关键词：

pancreas; pancreatic cancer; pancreas cancer; vein; prognosis; tumor immune microenvironment; venous invasion; PAPILLARY MUCINOUS NEOPLASMS; TO-MESENCHYMAL-TRANSITION; VOLUME DOUBLING TIME; LONG-TERM SURVIVAL; BREAST-CANCER; DUCTAL ADENOCARCINOMA; VASCULAR INVASION; PERINEURAL INVASION; VENOUS INVASION; NEURAL INVASION;

D O I：

10.1002/path.5260

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The remarkable aggressiveness of pancreatic cancer has never been fully explained. Although clearly multifactorial, we postulate that venous invasion, a finding seen in most pancreatic cancers but not in most cancers of other organs, may be a significant, underappreciated contributor to the aggressiveness of this disease. Copyright (c) 2019 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

引用

页码：131 / 141

页数：11

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