Drug-induced Immune Thrombocytopenia

被引：22
|
作者：
Chong, Beng H. [1 ,2 ]
Choi, Philip Young-Ill [2 ,3 ]
Khachigian, Levon [3 ]
Perdomo, Jose [2 ,3 ]
机构：
[1] St George Hosp, Dept Haematol, Kogarah, NSW 2217, Australia
[2] Univ New S Wales, St George Hosp, Dept Med, St George Clin Sch, Kogarah, NSW 2217, Australia
[3] Univ New S Wales, Ctr Vasc Res, Sydney, NSW 2033, Australia
来源：
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2013年 / 27卷 / 03期
关键词：
Drugs; Thrombocytopenia; Immune; Antibodies; QUININE-INDUCED THROMBOCYTOPENIA; HEPARIN-INDUCED THROMBOCYTOPENIA; PLATELET GLYCOPROTEIN IIB/IIIA; DEPENDENT ANTIBODIES; PROFOUND THROMBOCYTOPENIA; IN-VITRO; ANTIPLATELET ANTIBODIES; NONCYTOTOXIC DRUGS; NOD/SCID MOUSE; BINDING-SITE;
D O I：
10.1016/j.hoc.2013.02.003
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Thrombocytopenia is caused by immune reactions elicited by diverse drugs in clinical practice. The activity of the drug-dependent antibodies produces a marked decrease in blood platelets and a risk of serious bleeding. Understanding of the cellular mechanisms that drive drug-induced thrombocytopenia has advanced recently but there is still a need for improved laboratory tests and treatment options. This article provides an overview of the different types of drug-induced thrombocytopenia, discusses potential pathologic mechanisms, and considers diagnostic methods and treatment options.
引用
收藏
页码：521 / +
页数：21
相关论文
共 50 条
  • [1] Drug-induced immune thrombocytopenia
    van den Bemt, PMLA
    Meyboom, RHB
    Egberts, ACG
    DRUG SAFETY, 2004, 27 (15) : 1243 - 1252
  • [2] DRUG-INDUCED IMMUNE THROMBOCYTOPENIA
    KIEFEL, V
    MUELLERECKHARDT, C
    BLUT, 1988, 57 (04): : 215 - 215
  • [3] Drug-induced immune thrombocytopenia
    Matzdorff, Axel C.
    NEW ENGLAND JOURNAL OF MEDICINE, 2007, 357 (18): : 1870 - 1870
  • [4] DRUG-INDUCED IMMUNE THROMBOCYTOPENIA
    MOSS, RA
    AMERICAN JOURNAL OF HEMATOLOGY, 1980, 9 (04) : 439 - 446
  • [5] Drug-Induced Immune Thrombocytopenia
    Patricia M. L. A. van den Bemt
    Ronald H. B. Meyboom
    Antoine C. G. Egberts
    Drug Safety, 2004, 27 : 1243 - 1252
  • [6] Drug-induced immune thrombocytopenia - Reply
    Aster, Richard H.
    Bougie, Daniel W.
    NEW ENGLAND JOURNAL OF MEDICINE, 2007, 357 (18): : 1871 - 1871
  • [7] DRUG-INDUCED IMMUNE-THROMBOCYTOPENIA
    HOIGNE, R
    ACTA HAEMATOLOGICA, 1982, 68 (01) : 1 - 2
  • [8] Drug-induced immune-mediated thrombocytopenia
    Singh, Harpreet
    Dhibar, Deba
    Chaudhary, Deepak
    INDIAN JOURNAL OF PHARMACOLOGY, 2020, 52 (05) : 439 - 440
  • [9] Drug-induced immune thrombocytopenia: An overview of pathogenesis
    Aster, RH
    SEMINARS IN HEMATOLOGY, 1999, 36 (01) : 2 - 6
  • [10] Pathophysiology and Diagnosis of Drug-Induced Immune Thrombocytopenia
    Vayne, Caroline
    Guery, Eve-Anne
    Rollin, Jerome
    Baglo, Tatiana
    Petermann, Rachel
    Gruel, Yves
    JOURNAL OF CLINICAL MEDICINE, 2020, 9 (07) : 1 - 19
12345