Variations of serum IgG subclass levels in hepatitis C virus infection during interferon-alpha therapy

被引：5
|
作者：
Musset, L
Ghillani, P
Lunel, F
Cacoub, P
Cresta, P
Frangeul, L
Rosenheim, M
Preudhomme, JL
机构：
[1] GRP HOSP PITIE SALPETRIERE,VIROL LAB,F-75651 PARIS 13,FRANCE
[2] GRP HOSP PITIE SALPETRIERE,DEPT HEPATOGASTROENTEROL,F-75651 PARIS 13,FRANCE
[3] GRP HOSP PITIE SALPETRIERE,DEPT INTERNAL MED,F-75651 PARIS 13,FRANCE
[4] GRP HOSP PITIE SALPETRIERE,PUBL HLTH UNIT,F-75651 PARIS 13,FRANCE
[5] UNIV POITIERS HOSP,LAB IMMUNOL & IMMUNOPATHOL,CNRS URA 1172,POITIERS,FRANCE
来源：
IMMUNOLOGY LETTERS | 1997年 / 55卷 / 01期
关键词：
hepatitis C virus; IgG subclass; interferon-alpha;
D O I：
10.1016/S0165-2478(96)02681-8
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Serum IgG1 levels are selectively increased in patients with chronic hepatitis C virus (HCV) infection. In 15 patients who received interferon (IFN)-alpha therapy, serum levels of immunoglobulin classes and IgG subclasses were measured during treatment and after it was discontinued. In spite of important individual variations, mean IgG, IgG1, IgA and IgM levels decreased during therapy and tended to return to pre-treatment levels afterwards, with no detectable correlation with clinical and biological parameters. These results suggest an effect of IFN-alpha on in vivo immunoglobulin production, in HCV carriers. (C) 1997 Elsevier Science B.V.
引用
收藏
页码：41 / 45
页数：5
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