L-Proline/CeCl3•7H2O-NaI mediated stereoselective synthesis of α-2-deoxy glycosides from glucal

Glucal with different alcohols can be converted into the corresponding 2-deoxy glycosides without Ferrier rearrangement in high yield by treatment with eco friendly transition metal based catalysts [CuCl(3 center dot)2H(2)O-NaI (A) or CeCl3 center dot 7H(2)O-NaI (B)] and chiral amine ligand L-proline at various reaction conditions which were optimized for stereoselectivity. The catalyst CeCl3 center dot 7H(2)O-NaI (B) and ligand L-proline in toluene, was found to be much more efficient and high atom economic for the stereoselective glycosidation of propargyl alcohol with glucal, afforded exclusively alpha-2-deoxy propargyl glycoside in 98% optimized yield. The ligand L-proline was used for the first time in stereoselective glycosidation of alpha-2-deoxy glycosides involving glucal and alcohols. (c) 2018 Elsevier Ltd. All rights reserved.