Effect of invasive strategy on long-term mortality in elderly patients presenting with acute coronary syndrome

Objective: The elderly have the highest incidence of cardiovascular disease and frequently present with acute coronary syndrome (ACS) In this study, our aim was to evaluate the effect of an invasive strategy on long-term mortality in patients of 80 years and older presenting with ACS. Methods: Patients who were admitted to hospital with ACS were recruited using appropriate ICD codes in the computerised hospital data system. After exclusion of patients below 80 years old, the remaining 156 patients were involved in the final analyses. Ninety-four of 156 patients (60.3%) underwent coronary angiography and they constituted the invasive-strategy group, whereas the remaining 62 (39.7%) patients were treated medically and they constituted the conservative-strategy group. Results: Median follow-up duration of patients was 8.5 (0-61) months. Total mortality at the end of the follow-up period was 24 (25.5%) patients in the invasive-strategy group and 30 (48.4%) in the conservative-strategy group (p = 0.006). According to Cox regression analysis, the invasive strategy (OR: 0.26, 95% CI: 0.12-0.56. p = 0.001), presentation with ST-segment elevation myocardial infarction (OR: 7.76. 95% CI: 1.74-34,57, p = 0.002), low ejection fraction below 40% (OR: 3.11, 95% CI: 1.43-6.76, p = 0.004). heart rate (OR: 0.98, 95% CI: 0.96-0.99. p = 0.013) and GRACE risk score between 150 and 170 (OR: 7.76, 95% CI: 1.74-34.57, p = 0.002) were related to long-term mortality. Conclusions: Our results show the benefit of the invasive strategy on mortality rate in elderly patients over 80 years old and presenting with ACS.