Foldamers wave to the ribosome

被引：5
|
作者：
Schepartz, Alanna [1 ]
机构：
[1] Yale Univ, Dept Chem, Dept Mol Cellular & Dev Biol, New Haven, CT 06511 USA
来源：
NATURE CHEMISTRY | 2018年 / 10卷 / 04期
关键词：
ACID; TRANSLATION; PROTEINS;
D O I：
10.1038/s41557-018-0036-5
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Ribosomes have now been shown to accept certain initiator tRNAs acylated with aromatic foldamer-dipeptides thereby enabling the translation of a peptide or protein with a short aromatic foldamer at the N-terminus. Some foldamer-peptide hybrids could be cyclized to generate macrocycles that present conformationally restricted peptide loops.
引用
收藏
页码：377 / 379
页数：3
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