ENANTIOSELECTIVE SYNTHESIS OF BOTH ENANTIOMERS OF ETODOLAC VIA A LIPASE-CATALYZED KINETIC RESOLUTION

被引：4
|
作者：
Akai, Shuji [1 ]
Nemoto, Hiroyuki [1 ]
Egi, Masahiro [1 ]
机构：
[1] Univ Shizuoka, Sch Pharmaceut Sci, Suruga Ku, Shizuoka 4228526, Japan
来源：
HETEROCYCLES | 2008年 / 76卷 / 02期
关键词：
Kinetic Resolution; Lipase; Indole; Oxidation; Chemoselective Reaction;
D O I：
10.3987/COM-08-S(N)118
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The efficient preparation of both enantiomers of etodolac 1 was achieved by the lipase-catalyzed kinetic resolution of the racemic primary alcohol (+/-)-2 followed by chemoselective oxidation.
引用
收藏
页码：1537 / 1547
页数：11
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