A three-component, Zn(OTf)2-mediated entry into trisubstituted 2-aminoimidazoles

被引：5
|
作者：
Lukin, Alexei [1 ]
Bakholdina, Anna [1 ]
Kryukova, Anna [1 ]
Sapegin, Alexander [2 ]
Krasavin, Mikhail [2 ]
机构：
[1] MIREA Russian Technol Univ, Lomonosov Inst Fine Chem Technol, Moscow 119571, Russia
[2] St Petersburg State Univ, St Petersburg 199034, Russia
来源：
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 15卷
基金：
俄罗斯科学基金会;
关键词：
alkyne hydroamination; cyclocondensation; Lewis acid catalysis; multicomponent reactions; propargylurea;
D O I：
10.3762/bjoc.15.103
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A three-component reaction involving in situ generation of propargylureas and subsequent Zn(OTf)(2)-mediated cyclocondensation with a primary amine yielded trisubstituted 2-aminoimidazoles. These findings are in contrast to the previously reported base-promoted unimolecular cyclization of propargylureas (leading to 2-imidazolones) and extend the range of Lewis acid-catalyzed azole syntheses based on N-carbonyl propargylamines.
引用
收藏
页码：1061 / 1064
页数：4
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