Doxorubicin-Loaded Single Wall Nanotube Thermo-Sensitive Hydrogel for Gastric Cancer Chemo-Photothermal Therapy

被引：120
|
作者：
Zhou, Minyu [1 ]
Liu, Shuhan [1 ,2 ]
Jiang, Yaqi [1 ]
Ma, Huanrong [1 ]
Shi, Min [1 ]
Wang, Quanshi [3 ]
Zhong, Wen [4 ]
Liao, Wangjun [1 ]
Xing, Malcolm M. Q. [1 ,2 ,5 ,6 ]
机构：
[1] Southern Med Univ, Nanfang Hosp, Dept Oncol, Guangzhou 510515, Guangdong, Peoples R China
[2] Univ Manitoba, Dept Biochem & Med Genet, Dept Mech Engn, Winnipeg, MB R3T 5V6, Canada
[3] Southern Med Univ, Nanfang Hosp, Nanfang PET Ctr, Guangzhou 510515, Guangdong, Peoples R China
[4] Univ Manitoba, Dept Biosyst Engn, Winnipeg, MB R3T 5V6, Canada
[5] Childrens Hosp Res Inst Manitoba, Winnipeg, MB, Canada
[6] Univ Manitoba, Dept Mech Engn, Winnipeg, MB R3T 5V6, Canada
来源：
ADVANCED FUNCTIONAL MATERIALS | 2015年 / 25卷 / 29期
基金：
加拿大自然科学与工程研究理事会;
关键词：
drug delivery; gastric cancer; photothermal therapy; thermo-sensitive hydrogels; single-wall nanotubes; FUNCTIONALIZED CARBON NANOTUBES; DELIVERY; TRASTUZUMAB; INFUSION;
D O I：
10.1002/adfm.201501434
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Single wall carbon nanotube (SWNT) based thermo-sensitive hydrogel (SWNT-GEL) is reported, which provides an injectable drug delivery system as well as a medium for photothermal transduction. SWNT-hydrogel alone appears to be nontoxic on gastric cancer cells (BGC-823 cell line) but leads to cell death with NIR radiation through a hyperthermia proapoptosis mechanism. By incorporating hyperthermia therapy and controlled in situ doxorubicin (DOX) release, DOX-loaded SWNT-hydrogel with NIR radiation proves higher tumor suppression rate on mice xenograft gastric tumor models compared to free DOX without detectable organ toxicity. The developed system demonstrates improved efficacy of chemotherapeutic drugs which overcomes systemic adverse reactions and presents immense potential for gastric cancer treatment.
引用
收藏
页码：4730 / 4739
页数：10
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