The correlation analysis of RET gene polymorphism with papillary thyroid carcinoma

Objective: Thyroid cancer is a common malignant tumor occurred in head and neck. Studies also shown that the occurrence and development of thyroid cancer is related with some genes and gene polymorphisms. In this study, we used case control to test the polymorphisms of rs1799939 in RET gene exon 11. Methods: A total of 350 cases of papillary thyroid carcinoma (PTC) were collected, 320 healthy control were recruited from subject received routine medical examination. Their PCR product from blood sample and gene sequencing were performed to confirm their polymorphism distribution of rs1799939 in RET gene. Results: There is no difference in age and gender distribution between the 2 groups. correlation analysis showed the three genotypes frequency distribution (G/G, G/A and A/A) have no significant difference between PTC group and control group. There is statistical difference between PTC patients with different gender in gene frequency of rs1799939 site distributions (G/G, G/A and A/A) but not healthy control. In addition, the allele frequency distribution of G/A also have statistical difference (in gender frequency). "A" allele in rs1799939 did not increase the risk of PTC occurrence in female group. Conclusions: The polymorphism of rsl799939 locus is associated with the occurrence and development of PTC in the Han population in southern China.