TRPV4 antagonists ameliorate ventriculomegaly in a rat model of hydrocephalus

被引：31
|
作者：
Hochstetler, Alexandra E. [1 ]
Smith, Hillary M. [1 ]
Preston, Daniel C. [1 ]
Reed, Makenna M. [1 ]
Territo, Paul R. [2 ]
Shim, Joon W. [1 ]
Fulkerson, Daniel [3 ]
Blazer-Yost, Bonnie L. [1 ]
机构：
[1] Indiana Univ Purdue Univ, Dept Biol, Indianapolis, IN 46202 USA
[2] Indiana Univ Sch Med, Dept Radiol & Imaging Sci, Indianapolis, IN 46202 USA
[3] Beacon Childrens Hosp, South Bend, IN USA
来源：
JCI INSIGHT | 2020年 / 5卷 / 18期
关键词：
CHANNEL; MODULATION; CHILDREN;
D O I：
10.1172/jci.insight.137646
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Hydrocephalus is a serious condition that impacts patients of all ages. The standards of care are surgical options to divert, or inhibit production of, cerebrospinal fluid; to date, there are no effective pharmaceutical treatments, to our knowledge. The causes vary widely, but one commonality of this condition is aberrations in salt and fluid balance. We have used a genetic model of hydrocephalus to show that ventriculomegaly can be alleviated by inhibition of the transient receptor potential vanilloid 4, a channel that is activated by changes in osmotic balance, temperature, pressure and inflammatory mediators. The TRPV4 antagonists do not appear to have adverse effects on the overall health of the WT or hydrocephalic animals.
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页数：14
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