Design of experiments for locally weighted regression

被引:8
|
作者
Fedorov, VV
Montepiedra, G
Nachtsheim, CJ
机构
[1] SmithKline Beecham Pharmaceut, King Of Prussia, PA 19406 USA
[2] Bowling Green State Univ, Bowling Green, OH 43403 USA
[3] Univ Minnesota, Minneapolis, MN 55455 USA
关键词
mean squared error; D-optimal; linear-optimal; equivalence theorem; first-order algorithm; local regression;
D O I
10.1016/S0378-3758(99)00018-X
中图分类号
O21 [概率论与数理统计]; C8 [统计学];
学科分类号
020208 ; 070103 ; 0714 ;
摘要
We consider the design of experiments when estimation is to be performed using locally weighted regression methods. We adopt criteria that consider both estimation error (variance) and error resulting from model misspecification (bias). Working with continuous designs, we use the ideas developed in convex design theory to analyze properties of the corresponding optimal designs. Numerical procedures for constructing optimal designs are developed and applied to a variety of design scenarios in one and two dimensions. Among the interesting properties of the constructed designs are the following: (1) Design points tend to be more spread throughout the design space than in the classical case. (2) The optimal designs appear to be less model and criterion dependent than their classical counterparts. (3) While the optimal designs are relatively insensitive to the specification of the design space boundaries, the allocation of supporting points is strongly governed by the points of interest and the selected weight function, if the latter is concentrated in areas significantly smaller than the design region. Some singular and unstable situations occur in the case of saturated designs. The corresponding phenomenon is discussed using a univariate linear regression example. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:363 / 382
页数:20
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