Methemoglobinemia Induced by Trimethoprim-Sulfamethoxazole in a Patient with Systemic Lupus Erythematosus

被引：7
|
作者：
Kawasumi, Hidenaga [1 ]
Tanaka, Eiichi [1 ]
Hoshi, Daisuke [1 ]
Kawaguchi, Yasushi [1 ]
Yamanaka, Hisashi [1 ]
机构：
[1] Tokyo Womens Med Univ, Inst Rheumatol, Tokyo, Japan
来源：
INTERNAL MEDICINE | 2013年 / 52卷 / 15期
关键词：
methemoglobinemia; trimethoprim-sulfamethoxazole; systemic lupus erythematosus; MORTALITY; DEFICIENCY; INGESTION; GENOTYPE;
D O I：
10.2169/internalmedicine.52.0247
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We herein report a case of methemoglobinemia induced by trimethoprim-sulfamethoxazole (TMP/SMX). A 41-year-old woman with systemic lupus erythematosus (SLE) received TMP/SMX for prophylaxis of pneumocystis pneumonia (PCP) on the 7th day of hospitalization. She suddenly developed dyspnea and cyanosis on the 9th day of hospitalization. The level of oxygen saturation (SaO(2)) decreased, and the concentration of methemoglobin (MetHb) in the blood was elevated. We diagnosed the patient with methemoglobinemia induced by TMP/SMX. Methemoglobinemia should be considered in cases of sudden dyspnea following TMP/SMX administration.
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页码：1741 / 1743
页数：3
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